1,3-Dinitropyrene
1,3-Dinitropyrene structure
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Common Name | 1,3-Dinitropyrene | ||
|---|---|---|---|---|
| CAS Number | 75321-20-9 | Molecular Weight | 292.24600 | |
| Density | 1.574g/cm3 | Boiling Point | 493.9ºC at 760 mmHg | |
| Molecular Formula | C16H8N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 248ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes.
Cancer Res. 50(7) , 2036-43, (1990) NADPH-fortified human liver microsomes were examined with regard to ability to detoxicate several chemicals that do not require enzymatic oxidation to elicit a genotoxic response in a Salmonella typhimurium TA1535/pSK1002 system where umu response is used as ... |
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Modulation of the mutagenicity of three dinitropyrene isomers in vitro by rat-liver S9, cytosolic, and microsomal fractions following chronic ethanol ingestion.
Mutat. Res. 279(4) , 289-98, (1992) The effects of chronic ethanol feeding of rats on the ability of liver fractions to modulate the bacterial mutagenicity of three dinitropyrene isomers (1,3-, 1,6- and 1,8-DNP), which require bacterial enzymes but not an exogenous enzyme source for activation,... |
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Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan.
Mutat. Res. 538(1-2) , 121-31, (2003) To clarify the mutagenic potential of surface soil in the Kinki region of Japan, particularly in Osaka and neighboring cities, 62 surface soil samples were collected and their organic extracts were examined by the Ames/Salmonella assay. All of the samples wer... |
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High-performance liquid chromatography-fluorescence determination of dinitropyrenes in soil after column chromatographic clean-up and on-line reduction.
J. Chromatogr. A. 839(1-2) , 41-8, (1999) In order to quantify 1,3-dinitropyrene (DNP), 1,6-DNP and 1,8-DNP in soil, we developed an efficient clean-up procedure and a sensitive determination method using fluorescence detection. DNP isomers were efficiently cleaned by three stages of fractionation, i... |
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Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.
Mutat. Res. 472(1-2) , 129-38, (2000) The genotoxicities of four samples of diesel exhaust particle (DEP) extracts (DEPE) and nine nitroarenes found in DEPE were investigated after activation catalyzed by human cytochrome P450 (P450) family 1 enzymes co-expressed with NADPH-cytochrome P450 reduct... |
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Mutagenicity of airborne particulates from combustion of electric cables in a waste metal retrieval area.
Mutat. Res. 324(1-2) , 77-84, (1994) The disposal of massive quantities of synthetic materials has become a very serious environmental problem around the world. When synthetic polymers are burnt or smolder in air, the combustion products are extremely complex, often consisting of several hundred... |
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Carcinogenicity of dinitropyrenes in the weanling female CD rat.
Carcinogenesis 12(7) , 1187-91, (1991) The carcinogenicities of 1-nitropyrene and 1,3-, 1,6- and 1,8-dinitropyrene were assessed in weanling female CD rats. The animals were administered one of the compounds at 10 mumol/kg body wt through intraperitoneal or intragastric administration three times ... |
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Mutagenic effects of nitropyrenes in a soybean test system.
Mutat. Res. 320(1-2) , 59-68, (1994) The mutagenic activity of 1-nitropyrene (1-NP), 1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP) was assayed in heterozygous soybean plants (Y11y11), based on the appearance of mutational spots (yellow, dark green and t... |
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Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines.
Toxicol. Lett. 72(1-3) , 53-7, (1994) The cytotoxicity of polycyclic and monocyclic nitroarenes was tested in cell lines V79/NH, H4IIEC3/G-, 5L and BWI-J, which are distinguished by their specific expression of xenobiotic metabolizing enzymes. The results show that polycyclic nitroarenes differen... |
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Decreased clastogenicity of dinitropyrenes in Chinese hamster lung (CHL) subclone cells with low NADPH-cytochrome P-450 reductase activity.
Mutat. Res. 264(1) , 37-41, (1991) Clastogenic potentials of 1,3-, 1,6- and 1,8-dinitropyrenes (DNPs) were compared between Chinese hamster lung (CHL) cells and its subclone MM1 cells, which were recently isolated as menadione-resistant cells after treatment with MNNG. NADPH-cytochrome P-450 r... |