clobazam
clobazam structure
|
Common Name | clobazam | ||
|---|---|---|---|---|
| CAS Number | 22316-47-8 | Molecular Weight | 300.74000 | |
| Density | 1.335g/cm3 | Boiling Point | 643.8ºC at 760mmHg | |
| Molecular Formula | C16H13ClN2O2 | Melting Point | 162-164°C | |
| MSDS | Chinese USA | Flash Point | 343.2ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
|
A multi-targeted liquid chromatography-mass spectrometry screening procedure for the detection in human urine of drugs non-prohibited in sport commonly used by the athletes.
J. Pharm. Biomed. Anal. 117 , 47-60, (2015) This work presents an analytical method for the simultaneous analysis in human urine of 38 pharmacologically active compounds (19 benzodiazepine-like substances, 7 selective serotonin reuptake inhibitors, 4 azole antifungal drugs, 5 inhibitors of the phosphod... |
|
|
Development and validation of an LC-MS/MS method for the simultaneous analysis of 28 specific narcotic adulterants used in dietary supplements.
Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1029-39, (2015) The purpose of this study was to develop a method to analyse the concentration of multiple illegal narcotics present in dietary supplements. To this end, we established and optimised a procedure using LC-MS/MS simultaneously to analyse 28 narcotic compounds i... |
|
|
Partial epilepsy and developmental delay in infant with ring chromosome 14.
Genet. Couns. 24(1) , 81-3, (2013) Ring chromosome 14 (r14) is clinically characterized by early-onset epilepsy, mental retardation, delayed speech, microcephaly, extremely mild facial dysmorphisms and ophthalmologic abnormalities. We report a case presenting with partial seizures and delayed ... |
|
|
Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy.
Epileptic Disord. 15(2) , 132-41, (2013) The aim of this observational study was to obtain information regarding efficacy and safety of add-on levetiracetam (LEV; n=32) in Japanese patients with refractory partial seizures in an everyday clinical setting, relative to control AEDs (n=30). This is the... |
|
|
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study.
Epileptic Disord. 14(4) , 388-97, (2012) An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE).We recruited 25 consecutive patients with BTRE and uncontrolled seizures. A... |
|
|
Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome.
Epilepsia 53(7) , 1140-5, (2012) We previously reported a mutant mouse carrying a severe myoclonic epilepsy in infancy (SMEI) mutation in Scn1a. In this study, we examined the susceptibility to hyperthermia-induced seizures of heterozygous Scn1a mutant mice (Scn1a(RX/+)) and wild-type (Scn1a... |
|
|
Stiripentol: an example of antiepileptic drug development in childhood epilepsies.
Eur. J. Paediatr. Neurol. 16 Suppl 1 , S13-7, (2012) The efficacy of stiripentol (STP) in Dravet Syndrome (DS) was discovered first in an exploratory study in pediatric pharmacoresistant epilepsies. This efficacy signal, used as a proof of concept, led to - two independent multicenter randomized, double-blind, ... |
|
|
Paradoxical seizures and status epilepticus with newer antiepileptic drugs.
Neurol. India 59(3) , 479-80, (2011)
|
|
|
Clobazam in epilepsy.
Indian J. Pediatr. 67(1 Suppl) , S88-91, (2000) Clobazam, an anxiolytic agent has proved to be a broad spectrum antiepileptic. It is effective and well tolerated. It has been mainly used as an adjunctive therapy with other antiepileptic agents without much side effects. It is also recommended as monotherap... |
|
|
Randomized, phase III study results of clobazam in Lennox-Gastaut syndrome.
Neurology 77(15) , 1473-81, (2011) To evaluate efficacy and safety of clobazam, a 1,5-benzodiazepine, as adjunctive therapy for Lennox-Gastaut syndrome (LGS).Patients aged 2-60 years were randomized to placebo or clobazam 0.25, 0.5, or 1.0 mg/kg/day. Study consisted of 4-week baseline, 3-week ... |