6-Methylchrysene
6-Methylchrysene structure
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Common Name | 6-Methylchrysene | ||
|---|---|---|---|---|
| CAS Number | 1705-85-7 | Molecular Weight | 242.314 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 449.4±12.0 °C at 760 mmHg | |
| Molecular Formula | C19H14 | Melting Point | 161.5°C | |
| MSDS | N/A | Flash Point | 217.8±13.7 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Metabolism of chrysene, 5-methylchrysene, 6-methylchrysene and 5,6-dimethylchrysene in rat liver cytosol, in vitro, and in rat subcutaneous tissue, in vivo.
Chem. Biol. Interact. 77(2) , 203-21, (1991) The polynuclear aromatic hydrocarbon chrysene undergoes a bioalkylation substitution reaction in vitro, in rat liver cytosol preparations, and in vivo, in rat dorsal subcutaneous tissue to yield 6-methylchrysene as a metabolite. In addition, both 5-methyl- an... |
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Enhancing effect of a bay region methyl group on tumorigenicity in newborn mice and mouse skin of enantiomeric bay region diol epoxides formed stereoselectively from methylchrysenes in mouse epidermis.
Cancer Res. 47(20) , 5310-5, (1987) The stereochemistry of diol epoxide formation in mouse epidermis upon topical application of [3H]-1R,2R-dihydroxy-1,2-dihydro-5-methylchrysene ([3H]-5-MeC-1R,2R-diol) and [3H]-6-MeC-1R,2R-diol, and the tumorigenicity in mouse skin and in newborn mice of the R... |
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Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells.
Toxicology 247(2-3) , 93-101, (2008) Methylated chrysenes (MeChry) are important cigarette smoke constituents and 5-MeChry has been listed as possibly carcinogenic to humans. Although a major attention has been in past paid especially to mutagenic, tumor-initiating effects of MeChry, little is k... |
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High stereoselectivity in mouse skin metabolic activation of methylchrysenes to tumorigenic dihydrodiols.
Cancer Res. 47(14) , 3613-7, (1987) The stereoselectivity of mouse skin metabolic activation to dihydrodiols of the strong carcinogen 5-methylchrysene (5-MeC) and the weak carcinogen 6-methylchrysene (6-MeC) was investigated. Synthetic 1,2-dihydro-1,2-dihydroxy-5-methylchrysene (5-MeC-1,2-diol)... |
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Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes.
Cancer Res. 56(2) , 316-24, (1996) The metabolism of environmentally occurring methylated polynuclear aromatic hydrocarbons by human cytochrome P450 (P450) enzymes has not been examined previously. We compared the metabolism of the tobacco smoke constituents 5-methylchrysene (5-MeC), a strong ... |
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Comparative metabolic activation in mouse skin of the weak carcinogen 6-methylchrysene and the strong carcinogen 5-methylchrysene.
Cancer Res. 45(12 Pt 1) , 6406-42, (1985) We compared the metabolic activation in mouse skin of the weak carcinogen 6-methylchrysene, which lacks a bay region methyl group, and the strong carcinogen 5-methylchrysene, which has a bay region methyl group. Metabolites of 6-methyl-chrysene were prepared ... |