swainsonine
swainsonine structure
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Common Name | swainsonine | ||
|---|---|---|---|---|
| CAS Number | 72741-87-8 | Molecular Weight | 173.210 | |
| Density | 1.38±0.1 g/cm3 | Boiling Point | 353.3±21.0 °C at 760 mmHg | |
| Molecular Formula | C8H15NO3 | Melting Point | 144-145 ºC | |
| MSDS | Chinese USA | Flash Point | 209.7±20.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Production, HPLC analysis, and in situ apoptotic activities of swainsonine toward lepidopteran, Sf-21 cell line.
Biotechnol. Prog. 30(5) , 1196-205, (2014) Swainsonine, a secondary metabolite from Metarhizium anisopliae has been extensively studied in the complementary areas of therapeutics and toxicology. This work aims to develop a simple UV-HPLC method of analyses for swainsonine in Metarhizium fermentation b... |
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DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.
Nucleic Acids Res. 39 , D1035-41., (2011) DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, pharmacology, pharmacokinetics, metabolism and pharmaceutic... |
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Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo.
Oncol. Rep. 28(6) , 2091-100, (2012) Swainsonine, an extract from Astragalus membranaceus, exhibits broad inhibition of growth and pro-apoptotic activity in a number of tumor types. However, the underlying mechanism involved remains unclear. To investigate the effects and mechanisms of swainsoni... |
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Swainsonine as a lysosomal toxin affects dopaminergic neurons.
J. Neural Transm. Gen. Sect. 119(12) , 1483-90, (2012) Swainsonine (SW) is an indolizidine triol plant alkaloid isolated from the species Astragalus, colloquially termed locoweed. When chronically ingested by livestock and wildlife, symptoms include severe neuronal disturbance. Toxicity to the central and periphe... |
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Identification of a new locoweed (Oxytropis serioopetala) and its clinical and pathological features in poisoned rabbits.
J. Vet. Med. Sci. 74(8) , 989-93, (2012) By a series of experiments, we identified a new member of the locoweed family, Oxytropis serioopetala, that produces swainsonine, a phytotoxin harmful to livestock. In order to evaluate the toxicity of Oxytropis serioopetala, its extract was administered to t... |
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Optimization of different process variables for the production of an indolizidine alkaloid, swainsonine from Metarhizium anisopliae.
J. Basic Microbiol. 52(5) , 590-7, (2012) Swainsonine is a polyhydroxylated indolizidine alkaloid having anticancer, antimetastatic, antiproliferative and immunomodulatory activities and also potential therapeutic applications against AIDS. In the present study, ten isolates of M. anisopliae were scr... |
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Real encoded genetic algorithm and response surface methodology to optimize production of an indolizidine alkaloid, swainsonine, from Metarhizium anisopliae.
Folia Microbiol. (Praha) 58(5) , 393-401, (2013) Response surface methodology (RSM) and artificial neural network-real encoded genetic algorithm (ANN-REGA) were employed to develop a process for fermentative swainsonine production from Metarhizium anisopliae (ARSEF 1724). The effect of finally screened proc... |
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Use of antiadhesive peptide and swainsonine to inhibit metastasis.
Ann. N. Y. Acad. Sci. 551 , 421-41; discussion 441-2, (1988)
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A simple and sensitive HPLC-UV method for the determination of swainsonine in rat plasma and its application in a pharmacokinetic study.
Arzneimittelforschung 62(5) , 209-12, (2012) A simple, rapid, selective and sensitive HPLC-UV method was developed and validated for the determination of swainsonine (SWSN) in rat plasma. The analyte was extracted from rat plasma with methanol as the extraction solvent. The LC separation was performed o... |
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Swainsonine: a new antineoplastic immunomodulator.
J. Natl. Med. Assoc. 81(10) , 1049-56, (1989) Swainsonine, an indolizidine alkaloid with immunomodulatory activity, has been found to be effective in inhibiting metastatic dissemination and growth of primary tumors of both murine and human origins. The unique ability of swainsonine to exhibit antimetasta... |