Hoechst 33258 (trihydrochloride)
Hoechst 33258 (trihydrochloride) structure
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Common Name | Hoechst 33258 (trihydrochloride) | ||
|---|---|---|---|---|
| CAS Number | 23491-45-4 | Molecular Weight | 533.880 | |
| Density | N/A | Boiling Point | 643.1ºC at 760mmHg | |
| Molecular Formula | C25H27Cl3N6O | Melting Point | 314 °C | |
| MSDS | Chinese USA | Flash Point | 342.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Early life exposure to chronic intermittent hypoxia causes upper airway dilator muscle weakness, which persists into young adulthood.
Exp. Physiol. 100 , 947-66, (2015) What is the central question of this study? Chronic intermittent hypoxia (CIH) is a dominant feature of respiratory control disorders, which are common. We sought to examine the effects of exposure to CIH during neonatal development on respiratory muscle form... |
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Synoviocyte Derived-Extracellular Matrix Enhances Human Articular Chondrocyte Proliferation and Maintains Re-Differentiation Capacity at Both Low and Atmospheric Oxygen Tensions.
PLoS ONE 10(6) , e0129961, (2015) Current tissue engineering methods are insufficient for total joint resurfacing, and chondrocytes undergo de-differentiation when expanded on tissue culture plastic. De-differentiated chondrocytes show poor re-differentiation in culture, giving reduced glycos... |
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Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis.
Autophagy 11 , 1358-72, (2015) Autophagy is an essential process for eliminating ubiquitinated protein aggregates and dysfunctional organelles. Defective autophagy is associated with various degenerative diseases such as Parkinson disease. Through a genetic screening in Drosophila, we iden... |
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Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice.
Infect. Immun. 77(7) , 3080-9, (2009) Infection with Chlamydia muridarum in the mouse urogenital tract can induce both protective immunity and inflammatory pathologies, which has been used as a model for understanding the immune and pathogenic mechanisms of C. trachomatis infection. We compared t... |
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Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.
Neurobiol. Dis. 74 , 281-94, (2015) Histone acetylation is an epigenetic modification that plays a critical role in chromatin remodelling and transcriptional regulation. There is increasing evidence that epigenetic modifications may become compromised in aging and increase susceptibility to the... |
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Deciphering the interactions between chlorambucil and calf thymus DNA: a multi-spectroscopic and molecular docking study.
Arch. Biochem. Biophys. 566 , 7-14, (2015) Non-covalent interactions of chlorambucil with calf thymus DNA was investigated using multi-spectroscopic techniques and molecular docking study. Binding constant calculated was found to be 1.54×10(4)M(-1) at 290K, significantly lower than various known inter... |
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DNA vaccines targeting heavy chain C-terminal fragments of Clostridium botulinum neurotoxin serotypes A, B, and E induce potent humoral and cellular immunity and provide protection from lethal toxin challenge.
Hum. Vaccin. Immunother. 11 , 1961-71, (2015) Botulinum neurotoxins (BoNTs) are deadly, toxic proteins produced by the bacterium Clostridium botulinum that can cause significant diseases in humans. The use of the toxic substances as potential bioweapons has raised concerns by the Centers for Disease Cont... |
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Transplant of Very Small Embryoniclike Stem Cells to Spinal Cord Injury in a Rat Model Promotes Movement Recovery.
Exp. Clin. Transplant. 13 , 256-61, (2015) Very small embryoniclike stem cells are a population of small stem cells with embryonic characteristics that were identified in adult murine bone marrow. During the past decade, researchers have examined different alternatives for functional recovery after sp... |
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Probing cell-matrix interactions in RGD-decorated macroporous poly (ethylene glycol) hydrogels for 3D chondrocyte culture.
Biomed. Mater. 10 , 035016, (2015) Macroporous hydrogels have shown great promise as scaffolds for cartilage engineering by facilitating nutrition transport and tissue in growth. Cell-matrix adhesion-a fundamental process in tissue engineering-has shown a profound effect on subsequent cell phe... |
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The potential role of the glycoprotein osteoactivin/glycoprotein nonmetastatic melanoma protein B in pancreatic cancer.
Pancreas 44(2) , 302-10, (2015) Pancreatic ductal adenocarcinoma is still one of the deadliest solid cancers so the finding of new therapeutic approaches and novel targets are of utmost importance. Glycoprotein nonmetastatic melanoma protein B (GPNMB), initially termed glycoprotein nonmetas... |