Carbadox
Carbadox structure
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Common Name | Carbadox | ||
|---|---|---|---|---|
| CAS Number | 6804-07-5 | Molecular Weight | 262.22200 | |
| Density | 1.447g/cm3 | Boiling Point | 405.47°C (rough estimate) | |
| Molecular Formula | C11H10N4O4 | Melting Point | 239-240ºC | |
| MSDS | Chinese USA | Flash Point | 18°(64°F) | |
| Symbol |
GHS02, GHS07, GHS08 |
Signal Word | Danger | |
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Reduction of carbadox mediated by reaction of Mn(III) with oxalic acid.
Environ. Sci. Technol. 47(3) , 1357-64, (2013) Manganese(III) geocomponents are commonly found in the soil environment, yet their roles in many biogeochemical processes remain unknown. In this study, we demonstrated that Mn(III) generated from the reaction of MnO(2) and oxalic acid caused rapid and extens... |
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Determination of amprolium, carbadox, monensin, and tylosin in surface water by liquid chromatography/tandem mass spectrometry.
Rapid Commun. Mass Spectrom. 21(12) , 1944-50, (2007) Antibiotics present in the environment are recently considered as emerging contaminants, and have raised increasing concerns about their potential risks to ecosystems and human health. In addition to the utilization for treatment, antibiotics are also routine... |
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Antibiotics in feed induce prophages in swine fecal microbiomes.
MBio 2(6) , doi:10.1128/mBio.00260-11, (2011) Antibiotics are a cost-effective tool for improving feed efficiency and preventing disease in agricultural animals, but the full scope of their collateral effects is not understood. Antibiotics have been shown to mediate gene transfer by inducing prophages in... |
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Progress on the development and single-laboratory validation of a high-performance liquid chromatographic method for the determination of carbadox and pyrantel tartrate in type B and C medicated feeds.
J. AOAC Int. 92(1) , 26-33, (2009) Carbadox, an antimicrobial agent, and pyrantel tartrate, an anthelmintic, are feed additives that are often used in combination in the United States. The current AOAC methods for these analytes are spectrophotometric, using standard addition techniques. These... |
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Determination of Carbadox and metabolites of Carbadox and Olaquindox in muscle tissue using high performance liquid chromatography-tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 881-882 , 90-5, (2012) A sensitive and robust LC-APCI-MS/MS method has been developed for the unambiguous detection and quantitative determination of the antimicrobial agent Carbadox, its metabolite quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid the major ... |
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A determinative and confirmatory method for residues of the metabolites of carbadox and olaquindox in porcine tissues.
Anal. Chim. Acta 637(1-2) , 128-34, (2009) Carbadox (CBX) and olaquindox (OLQ) are used in swine feed for growth promotion, to improve feed efficiency, increase the rate of weight gain, control swine dysentery and bacterial enteritis in young swine. In 1991, the Joint FAO/WHO Expert Committee on Food ... |
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Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells
Food Chem. Toxicol. 47(2) , 328-34, (2009) Quinoxaline-1,4-dioxides derivatives have been widely used as animal growth promoter. This study was conducted to investigate the cytotoxicity and genotoxicity of quinoxaline-1,4-dioxides derivatives, namely carbadox, olaquindox and quinocetone, in Vero cells... |
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Controlling Salmonella infection in weanling pigs through water delivery of direct-fed microbials or organic acids. Part I: effects on growth performance, microbial populations, and immune status.
J. Anim. Sci. 90(1) , 261-71, (2012) Pigs (n = 88) weaned at 19 ± 2 d of age were used in a 14-d study to evaluate the effects of water-delivered direct-fed microbials (DFM) or organic acids on growth, immune status, Salmonella infection and shedding, and intestinal microbial populations after i... |
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Genotoxicity evaluation of Mequindox in different short-term tests.
Food Chem. Toxicol. 51 , 330-6, (2013) Quinoxaline-1,4-dioxides (QdNOs) are the potent heterocyclic N-oxides with interesting biological properties such as antibacterial, anticandida, antitubercular, anticancer and antiprotozoal activities. Here, we tested and compared the mequindox (MEQ) for muta... |
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Characterization of carbadox-induced mutagenesis using a shuttle vector pSP189 in mammalian cells.
Mutat. Res. 638(1-2) , 11-6, (2008) Carbadox, a quinoxaline 1,4-dioxide derivative, is a known mutagen with its functional mechanism yet to be well defined. In the present study we used a shuttle vector assay in vitro to uncover the functional details of carbadox-induced mutagenesis in mammalia... |