Metrifonate
Metrifonate structure
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Common Name | Metrifonate | ||
|---|---|---|---|---|
| CAS Number | 52-68-6 | Molecular Weight | 257.437 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 269.4±40.0 °C at 760 mmHg | |
| Molecular Formula | C4H8Cl3O4P | Melting Point | 77-81 °C | |
| MSDS | Chinese USA | Flash Point | 116.7±27.3 °C | |
| Symbol |
GHS07, GHS08, GHS09 |
Signal Word | Danger | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Multi-residue method for determination of 238 pesticides in Chinese cabbage and cucumber by liquid chromatography-tandem mass spectrometry: comparison of different purification procedures.
J. Agric. Food Chem. 62(47) , 11449-56, (2014) This paper describes the comparison of five sample cleanup procedures for the determination of 238 pesticides via triple quadrupole liquid chromatography-tandem mass spectrometry (LC-MS/MS, with only 10 min of chromatographic running time) in Chinese cabbage ... |
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Destruction of halogen-containing pesticides by means of detonation combustion.
Environ. Sci. Pollut. Res. Int. 20(2) , 855-61, (2013) Pesticides that contain a halogen functional group have been destructed by means of detonative combustion. The following compounds were examined: (1) atrazine-2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine-herbicide; (2) bromophos-O,4-bromo-2,5-dichlor... |
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Photoelectrocatalytic degradation of high COD dipterex pesticide by using TiO2/Ni photo electrode.
J. Environ. Sci. (China) 24(6) , 1149-56, (2012) A TiO2 thin film electrode deposited on porous nickel net (TiO2/Ni) was prepared by the sol-gel method, and the surface morphology, crystal structure features and the grain size were characterized by Field emission scan electron microscopy (FESEM) and X-ray d... |
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Metrifonate: a new agent for the treatment of Alzheimer's disease.
Am. J. Health Syst. Pharm. 56(5) , 427-32, (1999) The pharmacology, pharmacokinetics, clinical efficacy, and adverse effects of metrifonate, a long-acting cholinesterase inhibitor, are discussed. Attempts to correct the central cholinergic deficits associated with Alzheimer's disease have included administra... |
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Therapeutic and operational profiles of metrifonate and praziquantel in Schistosoma haematobium infection.
Arzneimittelforschung 49(7) , 557-65, (1999) A systematic analysis of the existing literature has been undertaken to compare the therapeutic and operational profiles of metrifonate (CAS 52-68-6), and praziquantel (CAS 55-268-74-1), two anti-schistosomal compounds. The criteria evaluated were therapeutic... |
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A matrix solid-phase dispersion method for the extraction of seven pesticides from mango and papaya.
J. Chromatogr. Sci. 48(9) , 750-4, (2010) A simple and effective extraction method based on matrix solid-phase dispersion was developed to determine trichlorfon, pyrimethanil, methyl parathion, tetraconazole, thiabendazole, imazalil, and tebuconazole in papaya and mango using gas chromatography-mass ... |
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Modulation of dopaminergic neurotransmission induced by sublethal doses of the organophosphate trichlorfon in cockroaches.
Ecotoxicol. Environ. Saf. 109 , 56-62, (2014) Organophosphate (OP) insecticides have been used indiscriminately, based on their high dissipation rates and low residual levels in the environment. Despite the toxicity of OPs to beneficial insects is principally devoted to the acetylcholinesterase (AChE) in... |
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Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats.
Toxicol. Mech. Methods 21(8) , 585-90, (2011) Metrifonate (trichlorfon) is an inhibitor of acetylcholinesterase (AChE). It was used as an Alzheimer's disease (AD) drug; however, the application was withdrawn due to adverse effects. Implication of metrifonate for the antioxidant status and regulation of a... |
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A new gyrodactylid (Monogenea) parasitizing bay pipefish (Syngnathus leptorhynchus) from the Pacific Coast of North America.
J. Parasitol. 99(2) , 183-8, (2013) Gyrodactylus leptorhynchi n. sp. (Monogenea) is described from bay pipefish ( Syngnathus leptorhynchus ) (Syngnathidae) in coastal waters of southern California and British Columbia, and from an outbreak of gyrodactylosis at the Cabrillo Marine Aquarium in Ca... |