Novobiocin Sodium Salt
Novobiocin Sodium Salt structure
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Common Name | Novobiocin Sodium Salt | ||
|---|---|---|---|---|
| CAS Number | 1476-53-5 | Molecular Weight | 634.60600 | |
| Density | 1.42g/cm3 | Boiling Point | 848.2ºC at 760mmHg | |
| Molecular Formula | C31H35N2NaO11 | Melting Point | 215-220ºC | |
| MSDS | Chinese USA | Flash Point | 466.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Light scattering sensor for direct identification of colonies of Escherichia coli serogroups O26, O45, O103, O111, O121, O145 and O157.
PLoS ONE 9(8) , e105272, (2014) Shiga-toxin producing Escherichia coli (STEC) have emerged as important foodborne pathogens, among which seven serogroups (O26, O45, O103, O111, O121, O145, O157) are most frequently implicated in human infection. The aim was to determine if a light scatterin... |
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Mechanistic insights into Mg2+-independent prenylation by CloQ from classical molecular mechanics and hybrid quantum mechanics/molecular mechanics molecular dynamics simulations.
Biochemistry 53(30) , 5034-41, (2014) Understanding the mechanism of prenyltransferases is important to the design of engineered proteins capable of synthesizing derivatives of naturally occurring therapeutic agents. CloQ is a Mg(2+)-independent aromatic prenyltransferase (APTase) that transfers ... |
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Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates.
Pharm. Res. 32(5) , 1634-47, (2015) To evaluate whether the impact of functional modulation of the breast cancer resistance protein (BCRP, ABCG2 421C>A) on human pharmacokinetics after oral administration is predictable using Bcrp knockout mice and cynomolgus monkeys pretreated with a BCRP inhi... |
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Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range.
Oncotarget 5(10) , 3287-306, (2014) The microenvironment is increasingly recognized as a crucial aspect of cancer. In contrast and complement to the field's focus on biochemical factors and extracellular matrix, we characterize a novel aspect of host:tumor interaction - endogenous bioelectric s... |
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A combination of direct viable count and fluorescence in situ hybridization for specific enumeration of viable Lactobacillus delbrueckii subsp.bulgaricus and Streptococcus thermophilus.
Lett. Appl. Microbiol. 54(3) , 247-54, (2012) We have developed a direct viable count (DVC)-FISH procedure for quickly and easily discriminating between viable and nonviable cells of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus strains, the traditional yogurt bacteria.direct... |
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A comparison of rapid bacterial methods to U.S. EPA-approved methods for biosolids.
Water Environ. Res. 85(7) , 643-9, (2013) The U.S. Environmental Protection Agency (U.S. EPA) specifies methods for testing microorganisms in biosolids, including U.S. EPA Methods 1680 and 1682 for fecal coliforms and Salmonella sp., respectively. However, these methods require 3 to 5 days to complet... |
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New role of antibody in bacterial isolation.
J. AOAC Int. 95(1) , 216-21, (2012) To eliminate the interference caused by Pseudomonas aeruginosa in the isolation of Salmonella, a rabbit polyclonal antibody against P. aeruginosa was prepared by inoculating four New Zealand rabbits with the pathogen. The antiserum was purified using saturate... |
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KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability.
Exp. Diabetes Res. 2012 , 671673, (2012) KU-32 is a novel, novobiocin-based Hsp90 inhibitor that protects against neuronal glucotoxicity and reverses multiple clinical indices of diabetic peripheral neuropathy in a rodent model. However, any drug with potential for treating diabetic complications mu... |
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Synthesis, antimicrobial activity and molecular modeling study of substituted 5-aryl-pyrimido[5,4-c]quinoline-2,4-diones.
J. Enzyme Inhib. Med. Chem. 28(3) , 530-8, (2013) A series of pyrimido[5,4-c]quinoline-2,4-dione derivatives 5a-k were synthesized in moderate yields via a thermolysis reaction of equimolar ratio of 5-arylidine-1,3-dimethylbarbituric acid derivatives 3a-d with aniline derivatives 4a-d at 150-180 °C for 1-2 h... |
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Pharmacologically tunable polyethylene-glycol-based cell growth substrate.
Acta Biomater. 9(9) , 8272-8, (2013) Biohybrid materials combining synthetic polymers with biological components are highly suited for tissue engineering in order to emulate the behavior of natural materials such as the extracellular matrix (ECM). In order to allow for an optimal cell-material i... |