2-iminothiolane
2-iminothiolane structure
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Common Name | 2-iminothiolane | ||
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| CAS Number | 4781-83-3 | Molecular Weight | 137.63100 | |
| Density | 1.27g/cm3 | Boiling Point | 142.6ºC at 760mmHg | |
| Molecular Formula | C4H8ClNS | Melting Point | 198-201 °C(lit.) | |
| MSDS | USA | Flash Point | 40.1ºC | |
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Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes.
Eur. J. Pharm. Sci. 62 , 23-32, (2014) Drug delivery from topically instilled eye drops to the posterior segment of the eye has long been one of the greatest challenges of ocular drug development. We developed methods of liposome preparation utilizing a microfluidizer to achieve adjustable nanopar... |
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Gelatin-siloxane nanoparticles to deliver nitric oxide for vascular cell regulation: synthesis, cytocompatibility, and cellular responses.
J. Biomed. Mater. Res. A 103(3) , 929-38, (2015) Nitric oxide (NO) is an important mediator in cardiovascular system to regulate vascular tone and maintain tissue homeostasis. Its role in vascular cell regulation makes it promising to address the post-surgery restenosis problem. However, the application of ... |
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In situ fabrication of cleavable peptide arrays on polydimethylsiloxane and applications for kinase activity assays.
Anal. Chim. Acta 865 , 53-9, (2015) Polydimethylsiloxane (PDMS) is widely used for microfabrication and bioanalysis; however, its surface functionalization is limited due to the lack of active functional groups and incompatibility with many solvents. We presented a novel approach for in situ fa... |
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Formation of N-substituted 2-iminothiolanes when amino groups in proteins and peptides are modified by 2-iminothiolane.
Anal. Biochem. 236(1) , 114-25, (1996) The reagent 2-iminothiolane (2-IT) is used to introduce thiol groups into proteins and peptides by reactions of their amino groups. In this study, we report that the thiol adduct initially formed by the reaction of an amine with 2-IT (a 4-mercaptobutyramidine... |
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Use of maleimide-thiol coupling chemistry for efficient syntheses of oligonucleotide-enzyme conjugate hybridization probes.
Bioconjug. Chem. 1 , 71-76, (1990) Two general methods which exploit the reactivity of sulfhydryl groups toward maleimides are described for the synthesis of oligonucleotide-enzyme conjugates for use as nonradioisotopic hybridization probes. In the first approach, 6-maleimidohexanoic acid succ... |
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Octreotide-conjugated PAMAM for targeted delivery to somatostatin receptors over-expressed tumor cells.
J. Drug Target. 22(5) , 428-38, (2014) An octreotide-conjugated polyamidoamine (PAMAM) dendrimer was synthesized and employed as nanocarriers of methotrexate (MTX), for targeting to the somatostatin receptors over-expressed tumor cells.PAMAM-PEG-octreotide (PPO) and PAMAM-PEG (PPG) were synthesize... |
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Simplified method for conjugating macrocyclic bifunctional chelating agents to antibodies via 2-iminothiolane.
Bioconjug. Chem. 1(3) , 222-6, (1990) A one-step method for conjugating macrocyclic chelators to antibodies using the protein modification reagent 2-iminothiolane controls aggregation, maintains immunoreactivity, and produces consistent chelate/antibody ratios. Conjugation conditions have been in... |
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Protein structural changes in keratin fibers induced by chemical modification using 2-iminothiolane hydrochloride: a Raman spectroscopic investigation.
Biopolymers 79(4) , 173-84, (2005) For the purpose of investigating in detail the influence of chemical modification using 2-iminothiolane hydrochloride (2-IT) on keratin fibers, the structure of cross-sections at various depths of white human hair, treated with 2-IT and then oxidized, was dir... |
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Preparation of bioconjugates of CdTe nanocrystals for cancer marker detection. Hu F, et al.
Nanotechnology 17(12) , 2972, (2006)
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Multifunctional micelles for cancer cell targeting, distribution imaging, and anticancer drug delivery. Huang CK, et al.
Adv. Funct. Mater. 17(14) , 2291-2297, (2007)
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