4-Nitrophenyl 4-Guanidinobenzoate Hydrochloride
4-Nitrophenyl 4-Guanidinobenzoate Hydrochloride structure
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Common Name | 4-Nitrophenyl 4-Guanidinobenzoate Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 19135-17-2 | Molecular Weight | 336.73000 | |
| Density | 1.44g/cm3 | Boiling Point | 559.7ºC at 760mmHg | |
| Molecular Formula | C14H13ClN4O4 | Melting Point | 241-243ºC | |
| MSDS | Chinese USA | Flash Point | 292.3ºC | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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Peptide splicing in a double-sequence analogue of trypsin inhibitor SFTI-1 substituted in the P₁ positions by peptoid monomers.
Biopolymers 104 , 206-12, (2015) Recently, we described a process of trypsin-assisted peptide splicing of analogs of trypsin inhibitor SFTI-1, that seems to be very similar to proteasome-catalyzed peptide splicing. Here, we show, for the first time, that a peptide-peptoid hybrid (peptomer) c... |
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Backbone cyclization of a recombinant cystine-knot peptide by engineered Sortase A.
FEBS Lett. 588(23) , 4487-96, (2015) Cyclotides belong to the family of cyclic cystine-knot peptides and have shown promise as scaffolds for protein engineering and pharmacological modulation of cellular protein activity. Cyclotides are characterized by a cystine-knotted topology and a head-to-t... |
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Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates.
J. Med. Chem. 29 , 514, (1986) The aryl 4-guanidinobenzoate, 4'-nitrophenyl 4-guanidinobenzoate (NPGB), is a potent inhibitor of sperm acrosin, an enzyme with an essential function in the fertilization process. NPGB prevents fertilization in a number of animal species and is a good lead co... |
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NPGB-induced inhibition of superoxide anion production by normal Lewis rat macrophages.
Neurochem. Res. 14(1) , 55-61, (1989) The treatment of Lewis rat peritoneal macrophages with p1-nitrophenyl p-guanidinobenzoate (NPGB) inhibited the superoxide anion production stimulated with phorbol myristate acetate (PMA). The addition of NPGB at the time of maximum superoxide generation was s... |
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Binding of the Ile-Val and Val-Val effector dipeptides to the binary adducts of bovine trypsinogen with Kunitz and Kazal inhibitors as well as the acylating agent p-nitrophenyl p-guanidinobenzoate. A thermodynamic and kinetic study.
J. Mol. Biol. 194(4) , 751-4, (1987) Thermodynamics and kinetics of binding of the Ile-Val and Val-Val effector dipeptides to the binary adducts of bovine trypsinogen with the bovine basic pancreatic trypsin inhibitor (BPTI, Kunitz inhibitor), the porcine pancreatic secretory inhibitor (PSTI, Ka... |
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Modification of acyl-plasmin-streptokinase complex with polyethylene glycol. Reduction of sensitivity to neutralizing antibody.
FEBS Lett. 193(1) , 44-8, (1985) Acyl-plasmin-streptokinase complex has advantages as a 'site' directed fibrinolytic agent with the active site protected from the plasma protease inhibitors. But, in clinical use, the fibrinolytic potential of this acyl-enzyme complex is modified or abolished... |
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Presence of prophenoloxidase in the humoral fluid of amphioxus Branchiostoma belcheri tsingtauense.
Fish Shellfish Immunol. 17(5) , 477-87, (2004) The presence of phenoloxidase (PO) activity in the humoral fluid of amphioxus Branchiostoma belcheri tsingtauense was electrophoretically and spectrophotometrically studied. The enzyme was present in the humoral fluid predominantly as an inactive proenzyme, p... |
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Demonstration of the interaction of native C1 with monomeric immunoglobulins and C1 inhibitor.
J. Immunol. 134(4) , 2559-63, (1985) The association of native C1 with physiologically relevant proteins was studied by ultracentrifugation. 125I-C1 was centrifuged through numerous sucrose density gradients, each of which contained a different concentration of monomeric (19S) IgM throughout the... |
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The action of thrombin on peptide p-nitroanilide substrates: hydrolysis of Tos-Gly-Pro-Arg-pNA and D-Phe-Pip-Arg-pNA by human alpha and gamma and bovine alpha and beta-thrombins.
Thromb. Res. 28(3) , 313-32, (1982) Human and bovine alpha-thrombins (greater than 90% alpha form) with high fibrinogen clotting activities (approximately 3,000 U.S. units/mg protein) exhibit similar Michaelis menten kinetics with the p-nitroanilide tripeptide substrates Tos-Gly-Pro-arg-pNA (Ch... |
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Essential role of the concentration of immobilized ligands in affinity chromatography: purification of guanidinobenzoatase on an ionized ligand.
J. Chromatogr. B. Biomed. Sci. Appl. 740(2) , 211-8, (2000) Guanidinobenzoatase, a plasma protein with possible application as a 'tumor marker', has been fully purified by one-step affinity chromatography. The affinity matrix was prepared by 'controlled' immobilization of an enzyme inhibitor (agmatine) onto commercial... |