Chlormethiazole hydrochloride
Chlormethiazole hydrochloride structure
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Common Name | Chlormethiazole hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 6001-74-7 | Molecular Weight | 297.52200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H9Cl2NS | Melting Point | 136 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro.
J. Pharm. Pharmacol. 66(11) , 1534-51, (2014) Naftopidil (NAF) is a chiral compound with two enantiomers (R(+)-NAF and S(-)-NAF) and is used as a racemic mixture in clinical practice. This study aims to investigate the metabolism of NAF enantiomers in pooled human liver microsomes (HLMs) and cytochrome P... |
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Chlormethiazole: effectiveness against toxic effects of cocaine in mice.
J. Pharmacol. Exp. Ther. 295 , 153-161, (2000) Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several experime... |
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Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome.
Neurochem. Int. 43 , 155-164, (2003) The serotonin (5-HT) syndrome is the most serious toxic interaction of antidepressants, but no pharmacotherapy has yet been established. In the present study, we created an animal model of the 5-HT syndrome by intraperitoneally injecting rats with clorgyline ... |
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Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors.
Eur. J. Pharmacol. 452 , 255-262, (2002) Clomethiazole is a gamma-aminobutyric acid (GABA)-mimetic agent with anticonvulsant, sedative and neuroprotective properties. The pharmacological actions of clomethiazole that underlie its functional profile have not been fully explored, but are known to resu... |