Tropic acid

Tropic acid Structure
Tropic acid structure
Common Name Tropic acid
CAS Number 552-63-6 Molecular Weight 166.17400
Density 1.262g/cm3 Boiling Point 322.5ºC at 760mmHg
Molecular Formula C9H10O3 Melting Point 116-118ºC(lit.)
MSDS USA Flash Point 163.1ºC

Targeted metabolomics in the expanded newborn screening for inborn errors of metabolism.

Mol. Biosyst. 11 , 1525-35, (2015)

Inborn errors of metabolism are genetic disorders due to impaired activity of enzymes, transporters, or cofactors resulting in accumulation of abnormal metabolites proximal to the metabolic block, lack of essential products or accumulation of by-products. Man...

A chiral separation strategy for acidic drugs in capillary electrochromatography using both chlorinated and nonchlorinated polysaccharide-based selectors.

Electrophoresis 35(19) , 2807-18, (2014)

A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy uses a 45 mM ammonium formate (pH 2.9)/ACN (35/65, v/v) mobi...

Commercial formaldehyde standard for mass calibration in mass spectrometry.

J. Mass Spectrom. 50(3) , 463-9, (2015)

Common calibration standards for mass spectrometry can be a source of many problems including instrument contamination, ionization suppression and formation of unidentified ions during subsequent analysis. In this article, we present a new approach for the ca...

The metabolism of atropine in man.

J. Pharm. Pharmacol. 38(10) , 781-4, (1986)

A metabolic pattern of atropine in man, based on the detection of radiolabelled products in urine by high performance liquid chromatography after administration of [3H]atropine sulphate to a normal volunteer is proposed. Noratropine (24%), atropine-N-oxide (e...

The isolation and identification of 6-hydroxycyclohepta-1,4-dione as a novel intermediate in the bacterial degradation of atropine.

Biochem. J. 293 ( Pt 1) , 115-8, (1993)

Growth of Pseudomonas AT3 on the alkaloid atropine as its sole source of carbon and nitrogen is nitrogen-limited and proceeds by degradation of the tropic acid part of the molecule, with the metabolism of the tropine being limited to the point of release of i...

Capillary electrophoresis of tropane alkaloids and glycoalkaloids occurring in Solanaceae plants.

Methods Mol. Biol. 384 , 171-203, (2008)

This chapter examines the role of capillary electrophoresis (CE) in the separation of tropane alkaloids, glycoalkaloids, and closely related compounds that have either pharmaceutical value or toxicological effects on humans. The latest significant development...

1-(5-Dimethylamino-1-naphthalenesulphonyl)-(S)-3-aminopyrrolidine (DNS-Apy) as a fluorescence chiral labelling reagent for carboxylic acid enantiomers.

Biomed. Chromatogr. 11(3) , 137-42, (1997)

1-(5-Dimethylamino-1-naphthalenesulphonyl)-(S)-3-aminopyrrolidi ne (DNS-Apy) has been synthesized for the separation of carboxylic acid enantiomers by high-performance liquid chromatography (HPLC) and sensitive detection. The reagent reacts with carboxylic ac...

GC-MS profiling of urinary organic acids evaluated as a quantitative method.

Clin. Chem. 42(10) , 1609-15, (1996)

We assessed the quantitative performances of a classical method for profiling urinary organic acids: ethyl acetate extraction/oxime-trimethylsilyl derivatization/GC-MS. Twenty-seven acids were quantified on the basis of specific ions in both scan and selected...

The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications.

Mol. Microbiol. 39(6) , 1434-42, (2001)

The term catabolon was introduced to define a complex functional unit integrated by different catabolic pathways, which are, or could be, co-ordinately regulated, and that catalyses the transformation of structurally related compounds into a common catabolite...

The presence of atropinesterase activity in animal plasma.

Naunyn Schmiedebergs Arch. Pharmacol. 373(3) , 230-6, (2006)

The enzyme atropinesterase (EC 3.1.1.10) causes the rapid hydrolysis of tropane alkaloids such as atropine and scopolamine. This enzyme is known to occur in a certain proportion of rabbits and some plants, although its presence in other animal species remains...