Acadesine (AICAR)
Acadesine (AICAR) structure
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Common Name | Acadesine (AICAR) | ||
|---|---|---|---|---|
| CAS Number | 2627-69-2 | Molecular Weight | 258.231 | |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 726.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C9H14N4O5 | Melting Point | 214-215 °C | |
| MSDS | Chinese USA | Flash Point | 393.1±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Differential effects of AMPK agonists on cell growth and metabolism.
Oncogene 34 , 3627-39, (2015) As a sensor of cellular energy status, the AMP-activated protein kinase (AMPK) is believed to act in opposition to the metabolic phenotypes favored by proliferating tumor cells. Consequently, compounds known to activate AMPK have been proposed as cancer thera... |
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Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.
PLoS ONE 10 , e0120295, (2015) Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and is associated with lower plasma levels ... |
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Stimulatory Effects of Balanced Deep Sea Water on Mitochondrial Biogenesis and Function.
PLoS ONE 10 , e0129972, (2015) The worldwide prevalence of metabolic diseases, including obesity and diabetes, is increasing. Mitochondrial dysfunction is recognized as a core feature of these diseases. Emerging evidence also suggests that defects in mitochondrial biogenesis, number, morph... |
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[6]-Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2-Mediated AS160-Rab5 Pathway and AMPK-Mediated Insulin Sensitizing Effects.
J. Cell. Biochem. 116 , 1401-10, (2015) [6]-Gingerol has been used to control diabetes and dyslipidemia; however, its metabolic role is poorly understood. In this study, [6]-gingerol increased adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation in mouse skeletal muscle C2C... |
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Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue.
J. Nutr. 144(12) , 1887-95, (2014) Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are the main products of microbial fermentation in the gut and might mediate some of the effects of gut microbiota and nutrition on development, metabolism, and pathogenesis of obes... |
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AMP-activated Protein Kinase Suppresses Biosynthesis of Glucosylceramide by Reducing Intracellular Sugar Nucleotides.
J. Biol. Chem. 290 , 18245-60, (2015) The membrane glycolipid glucosylceramide (GlcCer) plays a critical role in cellular homeostasis. Its intracellular levels are thought to be tightly regulated. How cells regulate GlcCer levels remains to be clarified. AMP-activated protein kinase (AMPK), which... |
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EPA-enriched phospholipids ameliorate cancer-associated cachexia mainly via inhibiting lipolysis.
Food Funct. 6 , 3652-62, (2015) Excessive loss of fat mass is considered as a key feature of body weight loss in cancer-associated cachexia (CAC). It affects the efficacy and tolerability of cancer therapy and reduces the quality and length of cancer patients' lives. The aim of the present ... |
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Berberine regulates neurite outgrowth through AMPK-dependent pathways by lowering energy status.
Exp. Cell Res. 334 , 194-206, (2015) As a widely used anti-bacterial agent and a metabolic inhibitor as well as AMP-activated protein kinase (AMPK) activator, berberine (BBR) has been shown to cross the blood-brain barrier. Its efficacy has been investigated in various disease models of the cent... |
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Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK.
Sci. Rep. 6 , 23130, (2016) Bluetongue virus (BTV), a complex double-stranded segmented RNA virus, has been found to initiate cellular autophagy for its own benefit. Here, with a view to understanding the underlying mechanisms, we first systematically dissected the exact signaling netwo... |
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Deficiency in adiponectin exaggerates cigarette smoking exposure-induced cardiac contractile dysfunction: Role of autophagy.
Pharmacol. Res. 100 , 175-89, (2015) Second hand smoke is an independent risk factor for cardiovascular disease. Adiponectin (APN), an adipose-derived adipokine, has been shown to offer cardioprotective effect through an AMPK-dependent manner. This study was designed to evaluate the impact of ad... |