(2S)-2-Amino-4-pentynoic acid
(2S)-2-Amino-4-pentynoic acid structure
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Common Name | (2S)-2-Amino-4-pentynoic acid | ||
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| CAS Number | 23235-01-0 | Molecular Weight | 113.115 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 272.1±35.0 °C at 760 mmHg | |
| Molecular Formula | C5H7NO2 | Melting Point | 232ºC | |
| MSDS | Chinese USA | Flash Point | 118.3±25.9 °C | |
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[Hydrogen sulfide inhibits Ca(2+)-induced mitochondrial permeability transition pore opening in spontaneously hypertensive rats].
Fiziol. Zh. 59(1) , 3-10, (2013) In experiments in vivo and in vitro on the mitochondria isolated from the control and spontaneously hypertensive rats (SHR) hearts, we studied the effects of a donor of hydrogen sulfide (H2S), NaHS, and H2S biosynthesis substrate, L-cysteine, on the sensitivi... |
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Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity
Eur. J. Pharmacol. 685(1-3) , 165-73, (2012) Clinical use of gentamicin over prolonged periods is limited because of dose- and time-dependent nephrotoxicity. Primarily, lysosomal phospholipidosis, intracellular oxidative stress and heightened inflammation have been implicated. Hydrogen sulphide is an en... |
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Interdependency of cystathione γ-lyase and cystathione β-synthase in hydrogen sulfide-induced blood pressure regulation in rats.
Am. J. Hypertens. 25 , 74-81, (2012) Hydrogen sulfide (H(2)S), an endogenous vasoactive agent, is produced by cystathionine γ-lyase (CGL) and cystathionine β-synthase (CBS) enzymes. This study was conducted to evaluate the relative contribution of these enzymes in regulating systemic arterial pr... |
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Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin.
Braz. J. Med. Biol. Res. 45(3) , 244-9, (2012) Animal models of gentamicin nephrotoxicity present acute tubular necrosis associated with inflammation, which can contribute to intensify the renal damage. Hydrogen sulfide (H2S) is a signaling molecule involved in inflammation. We evaluated the effect of DL-... |
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Influence of an unnatural amino acid side chain on the conformational dynamics of peptides.
ChemPhysChem 13(6) , 1522-34, (2012) In this work, a non-natural amino acid, H-propargylglycine-OH (Pra), is chosen to examine the side-chain effect on the backbone conformation of small peptides. The conformations of two synthesized Pra-containing tripeptides, Ac-Pra-Pra-NH(2) (PPTP) and Ac-Pra... |
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PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides.
Chem. Commun. (Camb.) 49(71) , 7839-41, (2013) The unsaturated side chain of l-propargylglycine (Pra) was used to study parahydrogen-induced polarization (PHIP) in synthetic oligopeptides. For the first time PHIP-induced NMR signal enhancement was demonstrated using model peptides bearing various function... |
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Is cystathionine gamma-lyase protein expressed in the heart?
Biochem. Biophys. Res. Commun. 428(4) , 469-74, (2012) Hydrogen sulfide (H(2)S) has emerged as an important gasotransmitter, offering protection against ischemia-reperfusion damage to the heart. Cystathionine gamma-lyase (CSE) is believed to be the major H(2)S-generating enzyme in the heart. Quite contrary to the... |
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Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty.
Mol. Med. Report. 5(6) , 1497-502, (2012) Peripheral artery disease (PAD) may lead to a poor quality of life. Although percutaneous transluminal angioplasty (PTA) is widely used for the treatment of PAD, restenosis remains a major drawback. Hydrogen sulfide (H2S) plays potential roles in many physiol... |
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The role of endogenous hydrogen sulfide in pathogenesis of chronotropic dysfunction in rats with cirrhosis.
Eur. J. Pharmacol. 696(1-3) , 130-5, (2012) Endogenous hydrogen sulfide is produced by cystathionine-γ-lyase and cystathionine-β-synthase in a variety of tissues and has recently been implicated in the regulation of cardiac functions. Acceleration of the heart rate in response to catecholamines is impa... |
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17β-estradiol induces vasorelaxation by stimulating endothelial hydrogen sulfide release.
Mol. Hum. Reprod. 19(3) , 169-76, (2013) Estrogen exerts vascular protective effects, but the underlying mechanisms remain to be understood fully. In recent years, hydrogen sulfide (H(2)S) has increasingly been recognized as an important signaling molecule in the cardiovascular system. Vascular H(2)... |