Chemical Communications 2013-09-14

PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides.

Marco Körner, Grit Sauer, Andreas Heil, Daichi Nasu, Martin Empting, Daniel Tietze, Stephan Voigt, Heiko Weidler, Torsten Gutmann, Olga Avrutina, Harald Kolmar, Tomasz Ratajczyk, Gerd Buntkowsky

Index: Chem. Commun. (Camb.) 49(71) , 7839-41, (2013)

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Abstract

The unsaturated side chain of l-propargylglycine (Pra) was used to study parahydrogen-induced polarization (PHIP) in synthetic oligopeptides. For the first time PHIP-induced NMR signal enhancement was demonstrated using model peptides bearing various functional side chains.