DL-Propargylglycine
DL-Propargylglycine structure
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Common Name | DL-Propargylglycine | ||
|---|---|---|---|---|
| CAS Number | 64165-64-6 | Molecular Weight | 113.115 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 272.1±35.0 °C at 760 mmHg | |
| Molecular Formula | C5H7NO2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 118.3±25.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Nanotherapeutic approach for opiate addiction using DARPP-32 gene silencing in an animal model of opiate addiction.
J. Neuroimmune Pharmacol. 10(1) , 136-52, (2015) Opiates act on the dopaminergic system of the brain and perturb 32 kDa dopamine and adenosine 3', 5'-monophosphate-regulated phosphoprotein (DARPP-32) function. The DARPP-32 mediated inhibition of protein phosphatase-1 (PP-1) and modulation of transcriptional... |
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H2S, a novel gasotransmitter, involves in gastric accommodation.
Sci. Rep. 5 , 16086, (2015) H2S is produced mainly by two enzymes:cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE), using L-cysteine (L-Cys) as the substrate. In this study, we investigated the role of H2S in gastric accommodation using CBS(+/-) mice, immunohistochemistry,... |
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Impact of endogenous hydrogen sulfide on toll-like receptor pathway in renal ischemia/reperfusion injury in rats.
Ren. Fail. 37 , 727-33, (2015) In this study, we investigated the impact of endogenous hydrogen sulfide (H2S) on toll-like receptors (TLRs)-mediated inflammatory response and apoptosis in renal ischemia-reperfusion injury (IRI). Twenty-four male Wistar rats were randomly divided into four ... |
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Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter.
Int. J. Mol. Sci. 16 , 12560-77, (2015) Hyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis and other cardiovascular diseases. Unfortunately, Hcy-lowering strategies were found to have limited effects in reducing cardiovascular events. The underlying mechanisms remain uncle... |
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Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver.
Nat. Commun. 6 , 6479, (2015) Across phyla, reduced nicotinamide adenine dinucleotide phosphate (NADPH) transfers intracellular reducing power to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR), thereby supporting fundamental housekeeping and antioxidant pathways. Here we s... |
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Liposomes for targeting hepatocellular carcinoma: use of conjugated arabinogalactan as targeting ligand.
Int. J. Pharm. 477(1-2) , 128-39, (2014) Present study investigates the potential of chemically modified (Shah et al., 2013) palmitoylated arabinogalactan (PAG) in guiding liposomal delivery system and targeting asialoglycoprotein receptors (ASGPR) which are expressed in hepatocellular carcinoma (HC... |
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Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats.
Inhal. Toxicol. 27(1) , 54-63, (2015) Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, t... |
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A H2S-Nampt dependent energetic circuit is critical to survival and cytoprotection from damage in cancer cells.
PLoS ONE 9(9) , e108537, (2014) We recently demonstrated that cancer cells that recover from damage exhibit increased aerobic glycolysis, however, the molecular mechanism by which cancer cells survive the damage and show increased aerobic glycolysis remains unknown. Here, we demonstrate tha... |
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Knockdown of EGFR inhibits growth and invasion of gastric cancer cells.
Cancer Gene Ther. 21(11) , 491-7, (2014) The epidermal growth factor receptor (EGFR) is an oncogenic trans-membranous receptor, which is overexpressed in multiple human cancers. However, the role of EGFR in gastric cancer (GC) is still elusive. In this study, we aimed to investigate the expression a... |
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Reduction of hydrogen sulfide synthesis enzymes in the esophagus of patients with achalasia: effect of hydrogen sulfide in achalasia.
Neurogastroenterol. Motil. 27 , 1274-81, (2015) The aim of the present study was to investigate whether the synthesis of endogenous hydrogen sulfide (H2 S) was altered in achalasia patients and to determine the effects of H2 S on esophageal motility.(1) Tissue samples in lower esophageal sphincter (LES) we... |