dl-3-hydroxynorvaline
dl-3-hydroxynorvaline structure
|
Common Name | dl-3-hydroxynorvaline | ||
|---|---|---|---|---|
| CAS Number | 2280-42-4 | Molecular Weight | 133.14600 | |
| Density | 1.237g/cm3 | Boiling Point | 328.4ºC at 760mmHg | |
| Molecular Formula | C5H11NO3 | Melting Point | 231.2℃ | |
| MSDS | USA | Flash Point | 152.4ºC | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
|
Perturbation of intestinal microvillar enzyme biosynthesis by amino acid analogs. Evidence that dimerization is required for the transport of aminopeptidase N out of the endoplasmic reticulum.
J. Biol. Chem. 265 , 14566-14571, (1990) The amino acid analogs canavanine, 3-hydroxynorvaline, thialysine, 6-fluorotryptophan, m-fluorotyrosine, and 2-fluorophenylalanine were incorporated into proteins, synthesized in pig intestinal mucosal explants, and their effect on molecular processing and in... |
|
|
The requirement of phosphorylation on a threonine residue in the acute regulation of steroidogenesis in MA-10 mouse Leydig cells.
J. Steroid Biochem. Mol. Biol. 46(3) , 337-47, (1993) In the present study we have used several non-phosphorylatable analogs of the amino acids threonine and serine to determine the role of phosphorylation in the acute regulation of steroidogenesis in MA-10 mouse Leydig tumor cells. Our results indicate that sub... |
|
|
Inhibition of steroidogenesis in rat adrenal cortex cells by a threonine analogue.
J. Steroid Biochem. Mol. Biol. 40(1-3) , 421-9, (1991) We have investigated the ability of amino acid analogues of serine and threonine to inhibit the increase in steroidogenesis elicited by addition of ACTH or cAMP in cells isolated from the rat adrenal cortex. We have found that the serine analogues, D, L-isose... |
|
|
Pre-prolactin accumulates in rat pituitary cells incubated with a threonine analog.
J. Biol. Chem. 255(15) , 7051-4, (1980) The proteolytic processing of rat pre-prolactin (Pre-Prl) to prolactin in isolated hemipituitaries was inhibited by the threonine analog, beta-hydroxynorvaline (Hnv). Pre-Prl accumulated as a major labeled intracellular product, even during pulse labeling lon... |
|
|
Effect of the threonine analog beta-hydroxynorvaline on the glycosylation and secretion of alpha 1-acid glycoprotein by rat hepatocytes.
J. Biol. Chem. 260(19) , 10847-55, (1985) The threonine analog beta-hydroxynorvaline (Hnv) is an inhibitor of asparagine-linked glycosylation. In the presence of the analog hepatocytes synthesized immunoreactive alpha 1-acid glycoprotein with 0-6 oligosaccharide chains. Pulse-chase experiments were c... |
|
|
Effects of puromycin and hydroxynorvaline on net production and intracellular degradation of collagen in human fetal lung fibroblasts.
Arch. Biochem. Biophys. 270(1) , 294-301, (1989) Amino acid substitutions in collagen that impair folding of the triple helix result in significant increases in intracellular degradation of newly synthesized collagen. We have studied the effects of agents that cause other kinds of defects in collagen: hydro... |
|
|
Inhibition of synthesis of herpesvirus (HSV-1) glycoproteins and endogenous fusion by beta-hydroxynorvaline in BHK-21 cells.
Virology 138(1) , 156-61, (1984) Treatment of HSV-infected BHK-21 cells with 5-10 mM of beta-hydroxynorvaline (Hnv), an analog of threonine which blocked attachment of oligosaccharides at the Asn-X-Thr sites, markedly inhibited the synthesis of all viral glycoproteins as well as the major ca... |
|
|
Efficacy of glycoprotein inhibitors alone and in combination with trifluridine in the treatment of murine herpetic keratitis.
Curr. Eye Res. 5(2) , 93-9, (1986) The present study examined the anti-herpetic effect of the glycoprotein inhibitors, hydroxynorvaline and 2-deoxyglucose, alone and in combination with trifluridine on murine ocular herpes. Following ocular inoculation with a large dose of HSV-1 RE strain (10(... |
|
|
[In situ biosynthesis of LH in cultured anterior pituitary cells: effects of GnRH].
Pathol. Biol. 35(8) , 1147-51, (1987) In order to investigate the biosynthetic pathway of LH subunits, anterior pituitary cells were cultured in the presence of [35S]Met and polypeptides immunologically-related (i.r.) to the alpha and LH beta subunits were isolated from cells and media using spec... |
|
|
[Activity of threonine deaminase and biosynthesis of avermectins in the culture of Streptomyces avermitilis].
Antibiot. Khimioter. 40 , 3-6, (1995) The influence of ammonium, threonine, isoleucine and valine on the activity of threonine deaminase and the biosynthesis of avermectins in the culture of two mutants of Streptomyces avermitilis, i.e. a sensitive one and a resistant one with respect to alpha-am... |