(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride

(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride Structure
(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride structure
Common Name (6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
CAS Number 69056-38-8 Molecular Weight 314.17
Density 1.9±0.1 g/cm3 Boiling Point 506.6±60.0 °C at 760 mmHg
Molecular Formula C9H17Cl2N5O3 Melting Point N/A
MSDS Chinese USA Flash Point 260.2±32.9 °C
Symbol GHS07
GHS07
Signal Word Warning

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Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate. This compound is then converted by subsequent enzymes, 6-p...

Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier.

Brain Res. 1352 , 208-13, (2010)

Glial-derived neurotrophic factor (GDNF) is a trophic factor for the nigra-striatal tract in experimental Parkinson's disease (PD). The neurotrophin must be administered by intra-cerebral injection, because GDNF does not cross the blood-brain barrier (BBB). I...

A new resorufin-based alpha-glucosidase assay for high-throughput screening.

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Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have ...

Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability.

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Endothelial barrier function is regulated by adherens junctions (AJs) and caveolae-mediated transcellular pathways. The opening of AJs that is observed in caveolin-1(-/-) (Cav-1(-/-)) endothelium suggests that Cav-1 is necessary for AJ assembly or maintenance...

Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration.

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We demonstrate for the first time that endomembrane-delimited H-Ras mediates VEGF-induced activation of endothelial nitric-oxide synthase (eNOS) and migratory response of human endothelial cells. Using thiol labeling strategies and immunofluorescent cell stai...

Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains.

Korean J. Physiol. Pharmacol. 17 , 89-97, (2013)

Developing an animal model for a specific disease is very important in the understanding of the underlying mechanism of the disease and allows testing of newly developed new drugs before human application. However, which of the plethora of experimental animal...

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