3-Cyano-7-ethoxycoumarin
3-Cyano-7-ethoxycoumarin structure
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Common Name | 3-Cyano-7-ethoxycoumarin | ||
|---|---|---|---|---|
| CAS Number | 117620-77-6 | Molecular Weight | 215.205 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 396.8±42.0 °C at 760 mmHg | |
| Molecular Formula | C12H9NO3 | Melting Point | 220-221ºC | |
| MSDS | Chinese USA | Flash Point | 173.6±18.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa.
Xenobiotica 42 , 989-1000, (2012) 1. Frutinone is an active ingredient extracted from the lipophilic fraction of the Polygala Fruticosa demonstrating various antibacterial and fungal properties. The aim of this study was to characterize its metabolism in an effort to understand metabolism bas... |
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Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity.
Expert Opin. Drug Metab. Toxicol. 10(10) , 1313-24, (2014) Drug resistance by Plasmodium falciparum remains a challenge in malaria chemotherapy. This paper will focus on physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid shown to have antimalarial activi... |
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Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.
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Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.
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Chemopreventive and therapeutic potentials of thymoquinone in HepG2 cells: mechanistic perspectives.
J. Nat. Med. 69 , 313-23, (2015) Liver cancer is the fifth commonest malignancy worldwide and the third leading cause of death. Identifying novel curative and preventive therapy may improve its prognosis. In this study, thymoquinone (TQ), the most active biological ingredient of Nigella sati... |
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Evaluation of the effects of 18 non-synonymous single-nucleotide polymorphisms of CYP450 2C19 on in vitro drug inhibition potential by a fluorescence-based high-throughput assay.
Xenobiotica 41(9) , 826-35, (2011) To comprehensively understand the effects of CYP2C19 genetic polymorphisms on inhibition-based drug-drug interactions (DDIs), 18 human CYP2C19 non-synonymous single-nucleotide polymorphic variants and the wild-type isoform (CYP2C19.1A) were expressed in yeast... |
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Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Mutat. Res. 523-524 , 163, (2003) Identification and use of effective cancer chemopreventive agents have become an important issue in public health-related research. For identification of potential cancer chemopreventive constituents we have set up a battery of cell- and enzyme-based in vitro... |
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Further characterization of the expression in liver and catalytic activity of CYP2B6.
J. Pharmacol. Exp. Ther. 286 , 1253, (1998) Previous studies in this laboratory have determined the lack of specificity of several antibody and substrate probes of CYP2B6. The goals of the current study were to examine the expression of CYP2B6 in a bank of human liver microsome (HLM) samples using a ne... |
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Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes.
Drug Metab. Dispos. 32 , 699, (2004) In this study we describe a battery of fluorescence assays for rapid measurement in intact cells of the activity of nine cytochromes P450 (P450s) involved in drug metabolism. The assays are based on the direct incubation of monolayers of cells expressing indi... |
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Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4.
Drug Metab. Dispos. 30 , 845, (2002) We have tested a panel of 29 cDNA-expressed rat and human enzymes with 9 fluorometric substrates to determine the P450 isoform selectivity in the catalysis of the substrates to fluorescent products. The substrates examined were dibenzyl fluorescein, 7-benzylo... |