Lathosterol
Lathosterol structure
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Common Name | Lathosterol | ||
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| CAS Number | 80-99-9 | Molecular Weight | 386.65400 | |
| Density | 0.98 g/cm3 | Boiling Point | 479.4ºC | |
| Molecular Formula | C27H46O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 208.9ºC | |
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Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(32) , 3806-11, (2011) Phytosterols (PS; β-sitosterol and campesterol) and cholesterol precursors (CP; desmosterol and lathosterol) have been suggested as important biochemical markers of cholesterol intestinal absorption and liver biosynthesis, respectively. Given that these compo... |
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Serum lipid responses to weight loss differ between overweight adults with familial hypercholesterolemia and those with familial combined hyperlipidemia.
J. Nutr. 144(8) , 1219-26, (2014) The effect of weight loss on lipids differs among individuals, although whether it can modify the management of hereditary hyperlipidemias has not yet been explored. The objective of this study was to examine the effect of weight loss on cholesterol metabolis... |
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Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients
Atherosclerosis 225(2) , 388-96, (2012) Objective Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates synthesis. We tested whether ezetimibe added to on-going stat... |
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Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease.
BMC Gastroenterol. 13 , 30, (2013) Gallstone disease is associated with p.D19H of ABCG8 as well as alterations of cholesterol and bile acid metabolism. However, molecular mechanisms have not been fully elucidated. It is important to understand the link between the sterol transporters ABCG5/8 a... |
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Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects
Atherosclerosis 219(2) , 761-7, (2011) Objective Subjects with high HDL-C show elevated plasma markers of cholesterol absorption and reduced markers of cholesterol synthesis. We evaluated the effect of dalcetrapib, a cholesteryl ester transfer protein modulator, on markers of cholesterol homeostas... |
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Inhibition of intestinal cholesterol absorption might explain cholesterol-lowering effect of telmisartan.
J. Clin. Pharm. Ther. 36(1) , 103-10, (2011) Telmisartan, an angiotensin II type 1 receptor blocker (ARB), acts as a partial agonist for peroxisome proliferator-activated receptor-γ, and thus improves abnormalities of glucose metabolism and hypertriglyceridaemia in addition to its documented blood press... |
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Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans.
Circ. J. 76(8) , 2023-30, (2012) Ezetimibe is an inhibitor of cholesterol absorption in the intestine. We examined whether ezetimibe improves endothelial function, and if so, what mechanisms are involved.Nineteen healthy subjects (male/female 14/5; mean age, 31±3 [SD] years-old) were randomi... |
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Cholesterol synthesis, cholesterol absorption, and mortality in hemodialysis patients.
Clin. J. Am. Soc. Nephrol. 7(6) , 943-8, (2012) Recent clinical trials on cholesterol-lowering in patients with CKD yielded conflicting results, which might have resulted from different treatment strategies. Serum cholesterol levels are determined by endogenous synthesis and intestinal absorption, which ar... |
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Efficacy and safety of ezetimibe in patients undergoing hemodialysis.
Endocr. J. 57(11) , 1001-5, (2010) Patients with dyslipidemia and advanced renal failure are at markedly increased risk of cardiovascular morbidity and mortality. We evaluated the efficacy and safety of ezetimibe administration to patients with endstage renal failure (ESRF) who are undergoing ... |
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Evolutionary genetics: no coming back from neverland.
Curr. Biol. 22(23) , R1004-6, (2012) Host-plant specialization plays a key role in insect evolution, but little is known about its molecular basis. A new paper shows that a cactus-feeding fly became restricted to its host by changes in an enzyme that converts dietary sterols into essential hormo... |