Lathosterol

Modify Date: 2024-01-03 18:27:54

Lathosterol Structure
Lathosterol structure
Common Name Lathosterol
CAS Number 80-99-9 Molecular Weight 386.65400
Density 0.98 g/cm3 Boiling Point 479.4ºC
Molecular Formula C27H46O Melting Point N/A
MSDS USA Flash Point 208.9ºC

 Use of Lathosterol


Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.

 Names

Name 5α-cholest-7-en-3β-ol
Synonym More Synonyms

 Lathosterol Biological Activity

Description Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Kempen HJ, et al. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J Lipid Res. 1988 Sep;29(9):1149-55.

 Chemical & Physical Properties

Density 0.98 g/cm3
Boiling Point 479.4ºC
Molecular Formula C27H46O
Molecular Weight 386.65400
Flash Point 208.9ºC
Exact Mass 386.35500
PSA 20.23000
LogP 7.38870
Index of Refraction 1.525
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FZ7000000
CHEMICAL NAME :
5-alpha-Cholest-7-en-3-beta-ol
CAS REGISTRY NUMBER :
80-99-9
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C27-H46-O
MOLECULAR WEIGHT :
386.73
WISWESSER LINE NOTATION :
L E5 B666 IUTJ A1 E1 FY1&3Y1&1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 19,977,1957

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS FZ7000000

 Synthetic Route

 Articles32

More Articles
Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(32) , 3806-11, (2011)

Phytosterols (PS; β-sitosterol and campesterol) and cholesterol precursors (CP; desmosterol and lathosterol) have been suggested as important biochemical markers of cholesterol intestinal absorption a...

Serum lipid responses to weight loss differ between overweight adults with familial hypercholesterolemia and those with familial combined hyperlipidemia.

J. Nutr. 144(8) , 1219-26, (2014)

The effect of weight loss on lipids differs among individuals, although whether it can modify the management of hereditary hyperlipidemias has not yet been explored. The objective of this study was to...

Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients

Atherosclerosis 225(2) , 388-96, (2012)

Objective Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates sy...

 Synonyms

Cholest-7-en-3beta-ol
Cholest-7-en-3-ol
5alpha-Cholest-7-en-3beta-ol
(3S,5S,9R,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
5alpha-cholest-7-en-3beta-ol
7-cholestenol
Lathosterol
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