Equilin
Equilin structure
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Common Name | Equilin | ||
|---|---|---|---|---|
| CAS Number | 474-86-2 | Molecular Weight | 268.350 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 459.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H20O2 | Melting Point | 238-240ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 195.4±21.3 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.
J. Med. Chem. 51 , 2047-56, (2008) A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data set by adding a number of nonsteroidal SHBG ligands identifi... |
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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
J. Med. Chem. 52 , 7488-502, (2009) 17beta-Hydroxysteroid dehydrogenase type 7 (17beta-HSD7) catalyzes the reduction of estrone (E(1)) into estradiol (E(2)) and of dihydrotestosterone (DHT) into 5alpha-androstane-3beta,17beta-diol (3beta-diol), therefore modulating the level of mitogenic estrog... |
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Comparison of the proliferative effects of estradiol and conjugated equine estrogens on human breast cancer cells and impact of continuous combined progestogen addition.
Climacteric 6(3) , 221-7, (2003) So far, most epidemiological studies investigating breast cancer risk and hormone replacement therapy have been conducted with conjugated equine estrogens (CEE). Recent trials indicate that the addition of progestogens may increase breast cancer risk. In the ... |
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Ozonation of a mixture of estrogens and progestins in aqueous solution: interpretation of experimental results by computational methods.
Chemosphere 89(11) , 1323-9, (2012) The degradation of the mixture of steroid hormones including seven estrogens (17α-estradiol, 17β-estradiol, 17α-dihydroequilin, 17α-ethinyl estradiol, estriol, estrone and equilin) and five progestins (levonorgestrel, gestodene, trimegestrone, medrogestone an... |
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Free synthetic and natural estrogen hormones in influent and effluent of three municipal wastewater treatment plants.
Water Environ. Res. 79(9) , 969-74, (2007) Three municipal wastewater treatment plants (WWTPs) in southeastern Pennsylvania were sampled to determine the presence and concentrations of 12 natural and synthetic estrogen hormones in the wastewater influent and effluent. The target estrogens were 17alpha... |
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Occurrence of estrogen hormones in biosolids, animal manure and mushroom compost.
Environ. Monit. Assess. 184(2) , 1197-205, (2012) The presence of natural estrogen hormones as trace concentrations in the environment has been reported by many researchers and is of growing concern due to its possible adverse effects on the ecosystem. In this study, municipal biosolids, poultry manure (PM) ... |
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B-ring unsaturated estrogens: biological evaluation of 17alpha-Dihydroequilein and novel B-Nor-6-thiaequilenins as tissue selective estrogens.
Bioorg. Med. Chem. Lett. 13(24) , 4281-4, (2003) The pharmacology and SAR of representative equine estogens is described. 17alpha-Dihydroequilenin was found to prevent bone loss after 5 weeks of oral administration to ovariectomized rats. The stereochemical significance of the D-ring and the C/D ring junctu... |
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Equine estrogens differentially prevent neuronal cell death induced by glutamate.
J. Soc. Gynecol. Investig. 10(5) , 302-8, (2003) In the present study, neuronal PC12 cells and hippocampal HT22 cells maintained in culture were used to test the neuroprotective effect of equine estrogens estrone, 17beta-estradiol, 17alpha-estradiol, equilin, 17beta-dihydroequilin, 17alpha-dihydroequilin, e... |
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Mixtures of estrogenic contaminants in bile of fish exposed to wastewater treatment works effluents.
Environ. Sci. Technol. 39(8) , 2461-71, (2005) Most effluents from wastewater treatment works (WwTWs) contain estrogenic chemicals that include steroidal estrogens and xenoestrogens. We investigated the nature of mixtures of estrogenic contaminants taken up by two species of fish exposed to two WwTWs effl... |
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The estrogen metabolite 17beta-dihydroequilenin counteracts interleukin-1alpha induced expression of inflammatory mediators in human endothelial cells in vitro via NF-kappaB pathway.
Thromb. Haemost. 95(1) , 107-16, (2006) In most studies showing cardio- and vasculoprotective effects of estrogens, 17beta-estradiol was used and little information on possible effects of different estrogen metabolites is yet available. We investigated whether particular estrogen metabolites are ef... |