Artemether
Artemether structure
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Common Name | Artemether | ||
|---|---|---|---|---|
| CAS Number | 71963-77-4 | Molecular Weight | 298.375 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 357.5±42.0 °C at 760 mmHg | |
| Molecular Formula | C16H26O5 | Melting Point | 86-89ºC | |
| MSDS | Chinese USA | Flash Point | 140.5±27.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.
Xenobiotica 44(7) , 615-26, (2014) 1. Cytochrome P450 enzyme system is the most important contributor to oxidative metabolism of drugs. Modification, and more specifically inhibition, of this system is an important determinant of several drug-drug interactions (DDIs). 2. Effects of the antimal... |
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Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application.
Int. J. Pharm. 477(1-2) , 208-17, (2014) NLC topical formulation as an alternative to oral and parenteral (IM) delivery of artemether (ART), a poorly water-soluble drug was designed. A Phospholipon 85G-modified Gelucire 43/01 based NLC formulation containing 75% Transcutol was chosen from DSC studie... |
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Neurotoxic effects of administration of artemisinin combination therapy (artemether and quinine) and ascorbic acid on the cytoarchitecture of the cerebellum and trapezoid nuclei in adult rats.
Afr. J. Med. Med. Sci. 41 Suppl , 149-55, (2012) This study investigated the neurotoxic effects of the combined intramuscular administration of Artemether (0.5 mg/kg/b.w.), Quinine (5.14 mg/kg/b.w.) and Ascorbic acid (0.21 mg/kg/b.w) on the cerebellum, trapezoid nuclei and behavioural functions in male Wist... |
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Artemether-lumefantrine co-administration with antiretrovirals: population pharmacokinetics and dosing implications.
Br. J. Clin. Pharmacol. 79(4) , 636-49, (2015) Drug-drug interactions between antimalarial and antiretroviral drugs may influence antimalarial treatment outcomes. The aim of this study was to investigate the potential drug-drug interactions between the antimalarial drugs, lumefantrine, artemether and thei... |
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Artemisinins, new miconazole potentiators resulting in increased activity against Candida albicans biofilms.
Antimicrob. Agents Chemother. 59(1) , 421-6, (2014) Mucosal biofilm-related fungal infections are very common, and the incidence of recurrent oral and vulvovaginal candidiasis is significant. As resistance to azoles (the preferred treatment) is occurring, we aimed at identifying compounds that increase the act... |
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Artemether-lumefantrine compared to atovaquone-proguanil as a treatment for uncomplicated Plasmodium falciparum malaria in travelers.
Am. J. Trop. Med. Hyg. 92(1) , 13-7, (2015) Atovaquone-proguanil (AP) and artemether-lumefantrine (AL) are both treatments for uncomplicated Plasmodium falciparum malaria, but comparative clinical trials are lacking. We performed a retrospective analysis, comparing treatment failure and fever clearance... |
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Quality of artemisinin-based combination formulations for malaria treatment: prevalence and risk factors for poor quality medicines in public facilities and private sector drug outlets in Enugu, Nigeria.
PLoS ONE 10 , e0125577, (2015) Artemisinin-based combination therapies are recommended by the World Health Organisation (WHO) as first-line treatment for Plasmodium falciparum malaria, yet medication must be of good quality for efficacious treatment. A recent meta-analysis reported 35% (79... |
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Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial.
PLoS Med. 11(12) , e1001773, (2014) Artemisinin combination therapies (ACTs) with broad efficacy are needed where multiple Plasmodium species are transmitted, especially in children, who bear the brunt of infection in endemic areas. In Papua New Guinea (PNG), artemether-lumefantrine is the firs... |
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New treatment policy of malaria as a part of malaria control program in Indonesia.
Acta Med. Indones. 44(3) , 265-9, (2012) Malaria control program is one of the oldest program in the Ministry of Health (MoH) Republic of Indonesia. Started with effort to eradicate malaria in 1959 through Malaria Eradication Command well known as KOPEM (Komando Pembasmian Malaria) then it evolves t... |
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In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae).
J. Parasitol. Res. 2015 , 872892, (2015) Malaria is an endemic disease globally and the conundrum of drug resistance has led to the search for newer antimalarial agents. The root extract of H. barteri was evaluated for antimalarial, analgesic, and anti-inflammatory properties. The prophylactic effec... |