Muscimol
Muscimol structure
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Common Name | Muscimol | ||
|---|---|---|---|---|
| CAS Number | 2763-96-4 | Molecular Weight | 114.103 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 325.0±27.0 °C at 760 mmHg | |
| Molecular Formula | C4H6N2O2 | Melting Point | 175-176ºC | |
| MSDS | Chinese USA | Flash Point | 150.4±23.7 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Frontostriatal systems comprising connections between ventral medial prefrontal cortex and nucleus accumbens subregions differentially regulate motor impulse control in rats.
Psychopharmacol. Ser. 232(7) , 1291-302, (2015) Deficits in impulse control are prevalent in several neuropsychiatric disorders that are based on impaired frontostriatal communication. The ventral medial prefrontal cortex (vmPFC) and the nucleus accumbens (NAc) are key substrates of impulse control in rats... |
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GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters.
Nat. Commun. 6 , 7879, (2015) The non-protein amino acid, gamma-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to biotic and abiotic stress, and regulates plant growth. Until now it was not known whether GABA exerts its effects in plants through the regulation o... |
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Optogenetic stimulation of mPFC pyramidal neurons as a conditioned stimulus supports associative learning in rats.
Sci. Rep. 5 , 10065, (2015) It is generally accepted that the associative learning occurs when a behaviorally neutral conditioned stimulus (CS) is paired with an aversive unconditioned stimulus (US) in close temporal proximity. Eyeblink conditioning (EBC) is a simple form of associative... |
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Nucleus accumbens core and shell inactivation differentially affects impulsive behaviours in rats.
Prog. Neuropsychopharmacol. Biol. Psychiatry 54 , 31-42, (2014) Impulsivity is a multifactorial phenomenon, determined by deficits in decision-making (impulsive choice) and impulse control (impulsive action). Recent findings indicate that impulsive behaviour is not only top-down controlled by cortical areas, but also modu... |
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Gene Transfer of Glutamic Acid Decarboxylase 67 by Herpes Simplex Virus Vectors Suppresses Neuropathic Pain Induced by Human Immunodeficiency Virus gp120 Combined with ddC in Rats.
Anesth. Analg. 120 , 1394-404, (2015) Human immunodeficiency virus (HIV)-related painful sensory neuropathies primarily consist of the HIV infection-related distal sensory polyneuropathy and antiretroviral toxic neuropathies. Pharmacotherapy provides only partial relief of pain in patients with H... |
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Adaptive categorization of sound frequency does not require the auditory cortex in rats.
J. Neurophysiol. 114 , 1137-45, (2015) A defining feature of adaptive behavior is our ability to change the way we interpret sensory stimuli depending on context. Rapid adaptation in behavior has been attributed to frontal cortical circuits, but it is not clear if sensory cortexes also play an ess... |
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Role of inhibition in respiratory pattern generation.
J. Neurosci. 33(13) , 5454-65, (2013) Postsynaptic inhibition is a key element of neural circuits underlying behavior, with 20-50% of all mammalian (nongranule) neurons considered inhibitory. For rhythmic movements in mammals, e.g., walking, swimming, suckling, chewing, and breathing, inhibition ... |
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Independent of 5-HT1A receptors, neurons in the paraventricular hypothalamus mediate ACTH responses from MDMA.
Neurosci. Lett. 555 , 42-6, (2013) Acute and chronic complications from the substituted amphetamine 3,4-methylenedioxymethamphetamine (MDMA) are linked to activation of the hypothalamic-pituitary-adrenal (HPA) axis. How MDMA activates the HPA axis is not known. HPA responses to stress are know... |
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Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4.
J. Neurosci. 34(25) , 8630-45, (2014) Correlative evidence suggests that GABAergic signaling plays an important role in the regulation of activity-dependent hippocampal neurogenesis and emotional behavior in adult mice. However, whether these are causally linked at the molecular level remains elu... |
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In vivo recordings of GnRH neuron firing reveal heterogeneity and dependence upon GABAA receptor signaling.
J. Neurosci. 33(22) , 9394-401, (2013) The gonadotropin-releasing hormone (GnRH) neurons are the key cells regulating fertility in all mammalian species. The scattered distribution of these neurons has made investigation of their properties extremely difficult and the key goal of recording their e... |