AH 6809
AH 6809 structure
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Common Name | AH 6809 | ||
|---|---|---|---|---|
| CAS Number | 33458-93-4 | Molecular Weight | 298.290 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 514.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H14O5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 192.9±23.6 °C | |
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Regulation of Expression of Renal Organic Anion Transporters OAT1 and OAT3 in a Model of Ischemia/Reperfusion Injury.
Cell Physiol. Biochem. 37 , 1-13, (2015) Recently, we gained evidence that impairment of rOat1 and rOat3 expression induced by ischemic acute kidney injury (AKI) is mediated by COX metabolites and this suppression might be critically involved in renal damage.(i) Basolateral organic anion uptake into... |
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Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells.
J. Immunol. 195 , 96-104, (2015) The localization of memory T cells to human skin is essential for long-term immune surveillance and the maintenance of barrier integrity. The expression of CCR8 during naive T cell activation is controlled by skin-specific factors derived from epidermal kerat... |
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Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Pulmonary Infection Caused by Pseudomonas aeruginosa via Inhibiting Overproduction of Prostaglandin E2.
Stem Cells 33 , 2331-42, (2015) New strategies for treating Pseudomonas aeruginosa pulmonary infection are urgently needed. Adipose tissue-derived mesenchymal stem cells (ASCs) may have a potential therapeutic role in P. aeruginosa-induced pulmonary infection.The therapeutic and mechanistic... |
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Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation.
Am. J. Respir. Cell. Mol. Biol. 51(2) , 242-50, (2014) Alveolar macrophages (AMs) represent the first line of innate immune defense in the lung. AMs use pattern recognition receptors (PRRs) to sense pathogens. The best studied PRR is Toll-like receptor (TLR)4, which detects LPS from gram-negative bacteria. The li... |
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Coordinated induction of cyclooxygenase-2/prostaglandin E2 and hepatocyte growth factor by apoptotic cells prevents lung fibrosis.
J. Leukoc. Biol. 94(5) , 1037-49, (2013) Apoptotic cell instillation after bleomycin induces persistent HGF production and protects from pulmonary fibrosis, but the underlying mechanism remains unclear. We investigated immediate and prolonged effects of in vivo instillation of apoptotic cells into b... |
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Increased cyclooxygenase-2-derived prostanoids contributes to the hyperreactivity to noradrenaline in mesenteric resistance arteries from offspring of diabetic rats.
PLoS ONE 7(11) , e50593, (2012) This study analyzed the effect of in utero exposure to maternal diabetes on contraction to noradrenaline in mesenteric resistance arteries (MRA) from adult offspring, focusing on the role of cyclooxygenase (COX)-derived prostanoids. Diabetes in the maternal r... |
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Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells.
Biol. Chem. 396(2) , 153-62, (2015) We analyzed signaling mechanisms for prostaglandin E2 (PGE2) production following activation of proteinase-activated receptor-1 (PAR1), a thrombin receptor, in preosteoblastic MC3T3-E1 cells. PAR1 stimulation caused PGE2 release, an effect suppressed by inhib... |
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Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma.
BMC Cancer 14 , 413, (2014) Several studies have described an increased cyclooxygenase-2 (COX-2) expression in pancreatic cancer, but the role of COX-2 in tumour development and progression is not clear. The aim of the present study was to examine expression of COX-2 in cancer cells and... |
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Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment.
Clin. Exp. Metastasis 32(4) , 335-44, (2015) Breast cancer can reoccur, often as bone metastasis, many years if not decades after the primary tumor has been treated. The factors that stimulate dormant metastases to grow are not known, but bone metastases are often associated with skeletal trauma. We use... |
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Prostaglandin E2elicits greater bronchodilation than salbutamol in mouse intrapulmonary airways in lung slices
Pulm. Pharmacol. Ther. 28(1) , 68-76, (2014) Background Current asthma therapy may not adequately target contraction of smaller intrapulmonary airways, which are a major site of airway obstruction and inflammation. The aim of this study was to characterise responses of mouse intrapulmonary airways to pr... |