Pulmonary Pharmacology & Therapeutics 2014-06-01

Prostaglandin E2elicits greater bronchodilation than salbutamol in mouse intrapulmonary airways in lung slices

M. FitzPatrick, C. Donovan, J.E. Bourke

Index: Pulm. Pharmacol. Ther. 28(1) , 68-76, (2014)

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Abstract

Background Current asthma therapy may not adequately target contraction of smaller intrapulmonary airways, which are a major site of airway obstruction and inflammation. The aim of this study was to characterise responses of mouse intrapulmonary airways to prostaglandin E2 (PGE2) and compare its dilator efficacy with the β2-adrenoceptor agonist salbutamol in situ, using lung slices.