Leptophos
Leptophos structure
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Common Name | Leptophos | ||
|---|---|---|---|---|
| CAS Number | 21609-90-5 | Molecular Weight | 412.06600 | |
| Density | 1.66 g/cm3 | Boiling Point | 444.4ºC at 760 mmHg | |
| Molecular Formula | C13H10BrCl2O2PS | Melting Point | 71-73 °C | |
| MSDS | Chinese USA | Flash Point | >100 °C | |
| Symbol |
GHS06, GHS08, GHS09 |
Signal Word | Danger | |
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Structural requirements of organophosphorus insecticides (OPI) to inhibit chicken yolk sac membrane kynurenine formamidase related to OPI teratogenesis.
Environ. Toxicol. Pharmacol. 35(2) , 200-6, (2013) This paper provides new information related to the mechanism of OPI (organophosphorus insecticides) teratogenesis. The COMFA (comparative molecular field analysis) and COMSIA (comparative molecular similarity indices analysis) suggest that the electrostatic a... |
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Effects of structure, atropine, and dosing regimen on the delayed neurotoxicity of the insecticide EPN.
Bull. Environ. Contam. Toxicol. 38(2) , 283-8, (1987)
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The role of pharmacokinetics and metabolism in species sensitivity to neurotoxic agents.
Fundam. Appl. Toxicol. 6(2) , 190-207, (1986) Attempts have been made to review the role of pharmacokinetics and metabolism in species and age sensitivity as well as the development of various toxic conditions of some neurotoxic chemicals. The route of administration may play a prominent role in the deve... |
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Peripheral nerve damage in chicks following treatment with organophosphorus compounds in ovo.
Toxicol. Appl. Pharmacol. 78(3) , 412-20, (1985) Chick embryos were treated with tri-o-cresyl phosphate (TOCP) or leptophos, organophosphorus compounds that cause delayed neurotoxicity. Embryos received either TOCP (62 or 250 microliter/kg egg) or leptophos (125 to 750 mg/kg egg) Day 14 of incubation and we... |
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The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds.
Toxicol. Lett. 143(1) , 65-71, (2003) To examine whether delayed neuropathy is prevented or alleviated when Ca is administered to experimental animals before or after organophosphorus compounds (OPs) dosing, we observed the effects of Calcicol administration as a calcium tonic on delayed neurotox... |
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Developmental toxicity of desbromoleptophos in chicks: enzyme inhibition, malformations and functional deficits.
Neurotoxicol. Teratol. 13(1) , 91-7, (1991) The relationship among inhibition of acetylcholinesterase (AChE), inhibition of neuropathy target enzyme (NTE), and developmental toxicity of the organophosphorus ester desbromoleptophos (DBL) was evaluated in chicks exposed on day 3 or day 15 of incubation o... |
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Acetylcholinesterase activity and degenerative changes in various segments of the spinal cord of hens induced by ingestion of subchronic levels of leptophos.
J. Environ. Sci. Health B 28(3) , 275-90, (1993) Changes in acetylcholinesterase (AChE) levels in the brain and various segments of the spinal cord of birds fed subchronic repeated oral doses of 0-(4-bromo-2,5 dichlorophenyl) 0-methyl phenylphosphonothioate, (leptophos, 15 mg/kg/day) is reported. The effect... |
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Effect of phenobarbital on the delayed neurotoxicity of leptophos in hens.
Arch. Environ. Contam. Toxicol. 15(6) , 653-9, (1986)
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Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens.
Tohoku J. Exp. Med. 185(3) , 161-71, (1998) Delayed neuropathy and inhibition of soluble neuropathy target esterase (NTE) and acetylcholinesterase (AChE) activities in different regions of brain and spinal cord of adult hens were studied after the intravenous administration of leptophos (30 mg/kg), tri... |
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Delayed neurotoxicity in the wild mallard duckling caused by the organophosphorus insecticides cyanofenphos and leptophos.
J. Environ. Sci. Health B 21(5) , 401-11, (1986) The susceptibility of wild mallard ducklings to the delayed neurotoxic effect of the neurotoxic organophosphorus insecticides cyanofenphos and leptophos was evaluated following a daily dosing regimen. Ducklings were treated daily with either cyanofenphos or w... |