SEW2871
SEW2871 structure
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Common Name | SEW2871 | ||
|---|---|---|---|---|
| CAS Number | 256414-75-2 | Molecular Weight | 440.362 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 490.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H10F6N2OS | Melting Point | 94.5-95.3ºC | |
| MSDS | Chinese USA | Flash Point | 250.3±31.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Differential activation of receptors and signal pathways upon stimulation by different doses of sphingosine-1-phosphate in endothelial cells.
Exp. Physiol. 100(1) , 95-107, (2015) What is the central question of this study? Why do different doses of sphingosine-1-phosphate (S1P) induce distinct biological effects in endothelial cells? What is the main finding and its importance? S1P at physiological concentrations preserved endothelial... |
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Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse.
J. Pharmacol. Exp. Ther. 352(1) , 61-6, (2014) Microvascular failure is hallmark of sepsis in humans and is recognized as a strong predictor of mortality. In the mouse subjected to cecal ligation and puncture (CLP) to induce a clinically relevant sepsis, renal microvascular permeability increases and peri... |
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Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells.
PLoS ONE 10 , e0143384, (2015) The plant flavonoid luteolin exhibits different biological effects, including anticancer properties. Little is known on the molecular mechanisms underlying its actions in colorectal cancer (CRC). Here we investigated the effects of luteolin on colon cancer ce... |
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Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration.
Biol. Chem. 396 , 803-12, (2015) Sphingosine 1-phosphate (S1P) is generated by sphingosine kinase (SK)-1 and -2 and acts mainly as an extracellular ligand at five specific receptors, denoted S1P1-5. After activation, S1P receptors regulate important processes in the progression of renal dise... |
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Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.
J. Lipid Res. 56 , 1134-44, (2015) Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is also inv... |
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S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes.
PLoS ONE 9(5) , e97196, (2014) Cardiopulmonary bypass (CPB) may induce systemic inflammation and vascular dysfunction. Sphingosine 1-phosphate (S1P) modulates various vascular and immune responses. Here we explored whether agonists of the S1P receptors, FTY720 and SEW2871 improve vascular ... |
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Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells.
Arterioscler. Thromb. Vasc. Biol. 28 , 925-31, (2008) High-density lipoproteins (HDL) are endowed with cardiovascular protective activities. In addition to their role in reverse cholesterol transport, HDL exert several beneficial effects on endothelial cells, including the induction of endothelial nitric oxide s... |
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S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure.
Kidney Int. 69 , 1601-8, (2006) The pathogenesis of renal ischemia/reperfusion (I/R) injury involves activating several signal transduction cascade systems in endothelial cells. Sphingosine 1-phospate (S1P) maintains endothelial cell integrity and inhibits lymphocyte egress via the specific... |
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Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice.
Arterioscler. Thromb. Vasc. Biol. 25 , 976-81, (2005) Endothelial activation and monocyte adhesion to endothelium are key events in inflammation. Sphingosine-1-phosphate (S1P) is a sphingolipid that binds to G protein-coupled receptors on endothelial cells (ECs). We examined the role of S1P in modulating endothe... |
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S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias.
J. Cardiovasc. Pharmacol. 50 , 660-9, (2007) Sphingosine-1-phosphate (S1P) has been considered to play an important role in ischemia/reperfusion (I/R) injury. We used SEW2871 (SEW), a novel receptor-selective agonist for S1P1, to elucidate the role of S1P1 in myocardial I/R. Isolated perfused rat hearts... |