[D-Ala2] -Deltorphin II
![[D-Ala2] -Deltorphin II Structure](https://image.chemsrc.com/caspic/081/122752-16-3.png)
[D-Ala2] -Deltorphin II structure
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Common Name | [D-Ala2] -Deltorphin II | ||
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| CAS Number | 122752-16-3 | Molecular Weight | 782.88300 | |
| Density | 1.272 g/cm3 | Boiling Point | 1256.2ºC at 760 mmHg | |
| Molecular Formula | C38H54N8O10 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 713.5ºC | |
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Membrane partitioning of various delta-opioid receptor forms before and after agonist activations: the effect of cholesterol.
Biochim. Biophys. Acta 1778(6) , 1483-92, (2008) Lipid rafts depicted as densely packed and thicker membrane microdomains, based on the dynamic clustering of cholesterol and sphingolipids, may help as platforms involved in a wide variety of cellular processes. The reasons why proteins segregate into rafts a... |
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Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice.
Eur. J. Neurosci. 32(11) , 1921-9, (2010) We have shown that delta opioid receptor (DOPR)-mediated analgesia was enhanced in the complete Freund's adjuvant (CFA) model of inflammation. This effect is thought to originate from translocation of DOPR in the plasma membrane of dorsal root ganglia and spi... |
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Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE.
Pharm. Res. 26(5) , 1226-35, (2009) To investigate whether conjunctival epithelial cells express transport processes for opioid peptides.We monitored the uptake of [(3)H]deltorphin II and [(3)H]DADLE, two hydrolysis-resistant synthetic opioid peptides, in the rabbit conjunctival epithelial cell... |
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Opioid δ(1) and δ(2) receptor agonist attenuate myocardial injury via mPTP in rats with acute hemorrhagic shock.
J. Surg. Res. 169(2) , 267-76, (2011) Studies have documented the beneficial roles of δ opioid receptor (OR) agonist for hemorrhagic shock. However, the myocardial protection roles and the mechanisms of hemodynamic stability during resuscitation of δ-OR agonist have not been explored. This study ... |
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Evidence for two different broad-specificity oligopeptide transporters in intestinal cell line Caco-2 and colonic cell line CCD841.
Am. J. Physiol. Cell Physiol. 300(6) , C1260-9, (2011) Recently the existence of two different Na(+)-coupled oligopeptide transport systems has been described in mammalian cells. These transport systems are distinct from the previously known H(+)/peptide cotransporters PEPT1 and PEPT2, which transport only dipept... |
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Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2.
Drug Metab. Pharmacokinet. 23(4) , 254-62, (2008) We have recently identified a Na+/Cl--coupled transport system in mammalian cells for endogenous and synthetic opioid peptides. This transport system does not transport dipeptides/tripeptides, but is stimulated by these small peptides. Here we investigated th... |
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Distinct inhibition of voltage-activated Ca2+ channels by delta-opioid agonists in dorsal root ganglion neurons devoid of functional T-type Ca2+ currents.
Neuroscience 153(4) , 1256-67, (2008) Both mu- and delta-opioid agonists selectively inhibit nociception but have little effect on other sensory modalities. Voltage-activated Ca(2+) channels in the primary sensory neurons are important for the regulation of nociceptive transmission. In this study... |
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Opioid peptide deltorphin II simulates the cardioprotective effect of ischemic preconditioning: role of δ₂-opioid receptors, protein kinase C, and K(ATP) channels.
Bull. Exp. Biol. Med. 149(5) , 591-3, (2010) The cardioprotective properties of a δ₂-opioid receptor agonist deltorphin II were studied in rats with coronary occlusion and reperfusion. Opioid receptor ligands and inhibitors (glybenclamide, chelerythrine, and 5-hydroxydecanoate) were injected intravenous... |
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Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis.
Biochem. Biophys. Res. Commun. 405(2) , 244-9, (2011) Retinal pigment epithelial cells (RPE) express two transport systems (SOPT1 and SOPT2) for oligopeptides. Hepcidin is an iron-regulatory peptide hormone consisting of 25 amino acids. This hormone binds to ferroportin, an iron exporter expressed on the cell su... |
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Comparison with naloxone of two dynorphin A analogues with K- and delta-opioid antagonist activity.
Med. Chem. 5(1) , 1-6, (2009) Recently, we have demonstrated that substitution of 1,2,3,4 tetrahyidroisoquinoline-3- carboxylic acid (Tic) in place of Gly2 in dynorphin A-(1-13)-NH2 (DYN) analogue (A) decreased the affinity to the kappa, delta, and micro receptors, and kappa selectivity. ... |