CGS 15943
CGS 15943 structure
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Common Name | CGS 15943 | ||
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| CAS Number | 104615-18-1 | Molecular Weight | 285.68900 | |
| Density | 1.72 g/cm3 | Boiling Point | 566.6ºC at 760 mmHg | |
| Molecular Formula | C13H8ClN5O | Melting Point | 278-279 °C | |
| MSDS | USA | Flash Point | 296.5ºC | |
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Adenosine induces growth-cone turning of sensory neurons.
Purinergic Signal. 4(4) , 357-64, (2008) The formation of appropriate connections between neurons and their specific targets is an essential step during development and repair of the nervous system. Growth cones are located at the leading edges of the growing neurites and respond to environmental cu... |
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Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.
Cancer Biol. Ther. 15(5) , 524-32, (2014) Caffeine is a naturally occurring methylxanthine that acts as a non-selective adenosine receptor antagonist. Epidemiological studies demonstrated habitual coffee drinking to be significantly associated with liver cancer survival. We aimed to investigate the e... |
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The effect of adenosine on pro-inflammatory cytokine production by porcine T cells.
Vet. Immunol. Immunopathol. 145(1-2) , 332-9, (2012) Adenosine is a well described anti-inflammatory modulator of immune responses. The aim of the present study was to describe the role of common adenosine agonist 5'-N-ethylcarboxamidoadenosine (NECA) in cytokine production by main porcine T cell subpopulations... |
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Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.
J. Med. Chem. 39 , 4142-4148, (1996) The adenosine antagonist 9-chloro-2-(2-furanyl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine (CGS15943) binds to human A3 receptors with high affinity (Ki = 14 nM), while it lacks affinity at rat A3 receptors. Acylated derivatives of the 5-amino group and other mo... |
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Reactive oxygen species contribute to the promotion of the ATP-mediated proliferation of mouse skeletal myoblasts.
Free Radic. Biol. Med. 53(7) , 1392-8, (2012) Reactive oxygen species (ROS) and extracellular adenosine 5'-triphosphate (ATP) participate in autocrine and paracrine regulation in skeletal muscle. However, the link between these two signaling systems is not well established. Here, we studied cell prolifer... |
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Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.
Br. J. Pharmacol. 159(4) , 772-86, (2010) The introduction of fluorescence-based techniques, and in particular the development of fluorescent ligands, has allowed the study of G protein-coupled receptor pharmacology at the single cell and single molecule level. This study evaluated how the physicoche... |
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Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation.
Eur. J. Pharmacol. 476(3) , 211-9, (2003) The role of adenosine in the cerebrovascular response to carbon dioxide inhalation was evaluated in two sets of experiments. The pial circulation was recorded by a Laser-Doppler flow probe placed over a closed cranial window in methoxyflurane anesthetized rat... |
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Identification of a small molecule PriA helicase inhibitor.
Biochemistry 51(51) , 10137-46, (2012) PriA helicase catalyzes the initial steps of replisome reloading onto repaired DNA replication forks in bacterial DNA replication restart pathways. We have used a high-throughput screen to identify a small molecule inhibitor of PriA-catalyzed duplex DNA unwin... |
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Promotion of forskolin-induced long-term potentiation of synaptic transmission by caffeine in area CA1 of the rat hippocampus.
Chin. J. Physiol. 42(4) , 249-53, (1999) Caffeine which is present in soft drinks has been shown to increase alertness and allays drowsiness and fatigue. The aim of this study is to investigate whether caffeine could produce a long-term effect on the synaptic transmission using extracellular recordi... |
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Binding of HTLV-1 virions to T cells occurs by a temperature and calcium-dependent process and is blocked by certain type 2 adenosine receptor antagonists.
Virus Res. 93(1) , 31-9, (2003) A flow cytometric assay that measures binding of human T-lymphotropic virus type 1 (HTLV-1) virions to target cells was used to investigate the binding process and to screen for compounds affecting viral binding. Results showed that adenosine receptor type 2 ... |