CGS 15943
CGS 15943 structure
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Common Name | CGS 15943 | ||
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| CAS Number | 104615-18-1 | Molecular Weight | 285.68900 | |
| Density | 1.72 g/cm3 | Boiling Point | 566.6ºC at 760 mmHg | |
| Molecular Formula | C13H8ClN5O | Melting Point | 278-279 °C | |
| MSDS | USA | Flash Point | 296.5ºC | |
Use of CGS 15943CGS 15943 is an adenosine A2 receptor antagonist and reduces stroke injury in the Mongolian gerbil[1]. CGS 15943 is a selectively p110γ inhibitor with an IC50 of 1.1 μM, shows inhibitory effect on p110δ (IC50=8.47 μM), has an anti-carcinogenic effect on HCC and PDAC cells[2]. |
| Name | 9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine |
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| Synonym | More Synonyms |
| Description | CGS 15943 is an adenosine A2 receptor antagonist and reduces stroke injury in the Mongolian gerbil[1]. CGS 15943 is a selectively p110γ inhibitor with an IC50 of 1.1 μM, shows inhibitory effect on p110δ (IC50=8.47 μM), has an anti-carcinogenic effect on HCC and PDAC cells[2]. |
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| Related Catalog | |
| Target |
p110γ:1.1 μM (IC50) p110δ:8.47 μM (IC50) adenosine A2 receptor |
| In Vitro | CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells[2]. CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells[2]. Cell Viability Assay[2] Cell Line: HLF, SK-Hep-1, HepG2 and PLC-PRF-5 cells Concentration: 0 μM; 1 μM; 5 μM; 10 μM; 20 μM Incubation Time: 24 hours Result: Inhibited growth of four distinct HCC cell lines. Western Blot Analysis[2] Cell Line: HLF and Sk-Hep-1 cells Concentration: 0 μM; 1 μM; 5 μM; 10 μM; 20 μM Incubation Time: 24 hours Result: Inhibited the PI3K/Akt pathway in HLF and Sk-Hep-1 cells |
| References |
| Density | 1.72 g/cm3 |
|---|---|
| Boiling Point | 566.6ºC at 760 mmHg |
| Melting Point | 278-279 °C |
| Molecular Formula | C13H8ClN5O |
| Molecular Weight | 285.68900 |
| Flash Point | 296.5ºC |
| Exact Mass | 285.04200 |
| PSA | 82.24000 |
| LogP | 3.35430 |
| Vapour Pressure | 7.4E-13mmHg at 25°C |
| Index of Refraction | 1.84 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Adenosine induces growth-cone turning of sensory neurons.
Purinergic Signal. 4(4) , 357-64, (2008) The formation of appropriate connections between neurons and their specific targets is an essential step during development and repair of the nervous system. Growth cones are located at the leading ed... |
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Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.
Cancer Biol. Ther. 15(5) , 524-32, (2014) Caffeine is a naturally occurring methylxanthine that acts as a non-selective adenosine receptor antagonist. Epidemiological studies demonstrated habitual coffee drinking to be significantly associate... |
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The effect of adenosine on pro-inflammatory cytokine production by porcine T cells.
Vet. Immunol. Immunopathol. 145(1-2) , 332-9, (2012) Adenosine is a well described anti-inflammatory modulator of immune responses. The aim of the present study was to describe the role of common adenosine agonist 5'-N-ethylcarboxamidoadenosine (NECA) i... |
| MFCD01529897 |