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CGS 15943

Names

[ CAS No. ]:
104615-18-1

[ Name ]:
CGS 15943

[Synonym ]:
MFCD01529897

Biological Activity

[Description]:

CGS 15943 is an adenosine A2 receptor antagonist and reduces stroke injury in the Mongolian gerbil[1]. CGS 15943 is a selectively p110γ inhibitor with an IC50 of 1.1 μM, shows inhibitory effect on p110δ (IC50=8.47 μM), has an anti-carcinogenic effect on HCC and PDAC cells[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

p110γ:1.1 μM (IC50)

p110δ:8.47 μM (IC50)

adenosine A2 receptor


[In Vitro]

CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells[2]. CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells[2]. Cell Viability Assay[2] Cell Line: HLF, SK-Hep-1, HepG2 and PLC-PRF-5 cells Concentration: 0 μM; 1 μM; 5 μM; 10 μM; 20 μM Incubation Time: 24 hours Result: Inhibited growth of four distinct HCC cell lines. Western Blot Analysis[2] Cell Line: HLF and Sk-Hep-1 cells Concentration: 0 μM; 1 μM; 5 μM; 10 μM; 20 μM Incubation Time: 24 hours Result: Inhibited the PI3K/Akt pathway in HLF and Sk-Hep-1 cells

[References]

[1]. Gao Y, et al. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 1994;55(3):PL61-5.

[2]. Edling CE, et al. Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biol Ther. 2014 May;15(5):524-32.

Chemical & Physical Properties

[ Density]:
1.72 g/cm3

[ Boiling Point ]:
566.6ºC at 760 mmHg

[ Melting Point ]:
278-279 °C

[ Molecular Formula ]:
C13H8ClN5O

[ Molecular Weight ]:
285.68900

[ Flash Point ]:
296.5ºC

[ Exact Mass ]:
285.04200

[ PSA ]:
82.24000

[ LogP ]:
3.35430

[ Vapour Pressure ]:
7.4E-13mmHg at 25°C

[ Index of Refraction ]:
1.84

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Adenosine induces growth-cone turning of sensory neurons.

Purinergic Signal. 4(4) , 357-64, (2008)

The formation of appropriate connections between neurons and their specific targets is an essential step during development and repair of the nervous system. Growth cones are located at the leading ed...

Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.

Cancer Biol. Ther. 15(5) , 524-32, (2014)

Caffeine is a naturally occurring methylxanthine that acts as a non-selective adenosine receptor antagonist. Epidemiological studies demonstrated habitual coffee drinking to be significantly associate...

The effect of adenosine on pro-inflammatory cytokine production by porcine T cells.

Vet. Immunol. Immunopathol. 145(1-2) , 332-9, (2012)

Adenosine is a well described anti-inflammatory modulator of immune responses. The aim of the present study was to describe the role of common adenosine agonist 5'-N-ethylcarboxamidoadenosine (NECA) i...


More Articles

Related Compounds