CP 73850
CP 73850 structure
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Common Name | CP 73850 | ||
|---|---|---|---|---|
| CAS Number | 110703-94-1 | Molecular Weight | 419.37700 | |
| Density | 1.58g/cm3 | Boiling Point | 598.7ºC at 760mmHg | |
| Molecular Formula | C19H12F3N3O3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 315.9ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
Eur. J. Pharmacol. 584 , 213-221, (2008) AKR1B10 is an aldose reductase (AR) homologue overexpressed in liver cancer and various forms of that enzyme in carcinomas catalyze the reduction of anticancer drugs, potential cytostatic drug, and dl-glyceraldehyde but do not catalyze the reduction of glucos... |
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Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages.
Cytokine 36(3-4) , 115-22, (2006) Aldose reductase (AR; AKR1B1) a member of aldo-keto reductase super family, that we had shown earlier mediates cytotoxic signals induced by high glucose, cytokines and growth factors, also mediates the inflammatory signals induced by Gram-negative bacterial e... |
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Endotoxin causes pulmonary hypertension by upregulating smooth muscle endothelin type-B receptors: role of aldose reductase.
Shock 30(2) , 189-96, (2008) Endothelin-1 (ET-1), a potent vasoconstrictor and mitogen, is upregulated in pulmonary tissue during endotoxemia and contributes markedly to endotoxin-induced pulmonary hypertension. It is, however, unknown whether the ET receptors, ET(A) and ET(B), are diffe... |
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Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells.
Exp. Eye Res. 90(5) , 555-63, (2010) Chronic inflammatory diseases such as autoimmune and bacterial infections are associated with an elevated risk of ocular inflammation. Ciliary epithelial cells that play an important role in maintaining aqueous humor dynamics and homeostasis of anterior segme... |
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Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells.
Nephrology (Carlton.) 11(2) , 105-12, (2006) To study the effects of aldose reductase (AR) on production of fibronectin and type IV collagen in rat mesangial cells (MsC).The vector, pcDNA3-AR, was constructed based on pET-15b-AR. Lipofect AMINE was used for stable transfection and G418 was used for sele... |
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Aldose reductase inhibitors zopolrestat and ferulic acid alleviate hypertension associated with diabetes: effect on vascular reactivity.
Can. J. Physiol. Pharmacol. 91(2) , 101-7, (2013) This study investigated the effect of aldose reductase (AR) inhibitors on hypertension in diabetes. Diabetes was induced with streptozotocin, while AR inhibitors zopolrestat and ferulic acid were administered at 2 weeks after streptozotocin treatment and for ... |
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Novel insights into the structural requirements for the design of selective and specific aldose reductase inhibitors.
J. Mol. Model. 18(5) , 1791-9, (2012) Aldose reductase (ALR2) plays a vital role in the etiology of long-term diabetic microvascular complications (DMCs) such as retinopathy, nephropathy and neuropathy. It initializes the polyol pathway and under hyperglycemic conditions, catalyzes the conversion... |
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The inhibition of aldose reductase on mucus production induced by interleukin-13 in the human bronchial epithelial cells.
Int. Immunopharmacol. 12(4) , 588-93, (2012) This study investigated whether aldose reductase (AR) inhibition affects interleukin (IL)-13-induced mucus production in the human bronchial epithelial cell line-16 (HBE16) cells. The HBE16 cells were cultured with AR inhibitors (zopolrestat) or were transfec... |
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Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase.
Biochim. Biophys. Acta 1810(9) , 879-87, (2011) Flexibility is a common feature of proteins. For human aldose reductase, a variety of conformers have been observed in crystalline complexes with different inhibitors.A study of crystal structures and isothermal titration calorimetry was performed on wild typ... |
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Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion.
Life Sci. 76(4) , 445-59, (2004) We investigated for the interaction between the polyol pathway and enhanced non-enzymatic glycation, both implicated in the pathogenesis of diabetic atherosclerosis, in the activation of aortic smooth muscle cell (SMC) function. Mouse aortas and primary cultu... |