Glucagon
Glucagon structure
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Common Name | Glucagon | ||
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| CAS Number | 9007-92-5 | Molecular Weight | 3519.21000 | |
| Density | N/A | Boiling Point | 230ºC at 760 mm Hg | |
| Molecular Formula | C153H226ClN43O49S | Melting Point | -15ºC | |
| MSDS | N/A | Flash Point | N/A | |
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Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice.
Metab. Clin. Exp. 64(2) , 283-95, (2015) Follistatin-like 3 (fstl3), a natural inhibitor of members of the TGF-β family, increases during resistance training in human plasma. Fstl3 primarily binds myostatin and activin A, and thereby inhibits their functions. We hypothesize that blocking myostatin a... |
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Comparison of the effects of slowly and rapidly absorbed carbohydrates on postprandial glucose metabolism in type 2 diabetes mellitus patients: a randomized trial.
Am. J. Clin. Nutr. 100(4) , 1059-68, (2014) Isomaltulose attenuates postprandial glucose and insulin concentrations compared with sucrose in patients with type 2 diabetes mellitus (T2DM). However, the mechanism by which isomaltulose limits postprandial hyperglycemia has not been clarified.The objective... |
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Glucagon secretion after metabolic surgery in diabetic rodents.
J. Endocrinol. 223(3) , 255-65, (2014) Excessive or inadequate glucagon secretion promoting hepatic gluconeogenesis and glycogenolysis is believed to contribute to hyperglycemia in patients with type 2 diabetes. Currently, metabolic surgery is an accepted treatment for obese patients with type 2 d... |
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Resveratrol ameliorates mitochondrial dysfunction but increases the risk of hypoglycemia following hemorrhagic shock.
J. Trauma Acute Care Surg. 77(6) , 926-33, (2014) Hemorrhagic shock (HS) may contribute to organ failure, by profoundly altering mitochondrial function. Resveratrol (RSV), a naturally occurring polyphenol, has been shown to promote mitochondrial function and regulate glucose homeostasis in diabetes. We hypot... |
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Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes.
Diabetes 64(1) , 72-8, (2015) Glucose-dependent insulinotropic polypeptide (GIP) is glucagonotropic, and glucagon-like peptide-1 (GLP-1) is glucagonostatic. We studied the effects of GIP and GLP-1 on glucagon responses to insulin-induced hypoglycemia in patients with type 1 diabetes melli... |
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Lipopolysaccharide impairs hepatocyte ureagenesis from ammonia: Involvement of mitochondrial aquaporin-8
FEBS Lett. 588(9) , 1686-91, (2014) • Lipopolysaccharide down-regulates hepatocyte mitochondrial aquaporin-8 expression. • Lipopolysaccharide decreases mitochondrial ammonia diffusional permeability. • Lipopolysaccharide impairs hepatocyte ureagenesis from ammonia. • A role for aquaporin-8 in d... |
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Effect of the glucagon-like peptide-1 receptor agonist lixisenatide on postprandial hepatic glucose metabolism in the conscious dog.
Am. J. Physiol. Endocrinol. Metab. 305(12) , E1473-82, (2013) The impact of the GLP-1 receptor agonist lixisenatide on postprandial glucose disposition was examined in conscious dogs to identify mechanisms for its improvement of meal tolerance in humans and examine the tissue disposition of meal-derived carbohydrate. Ca... |
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Conditional glucagon receptor overexpression has multi-faceted consequences for beta-cell function.
Metab. Clin. Exp. 63(12) , 1568-76, (2014) Although it is known that the islet expression of glucagon receptors is increased in type 2 diabetes, its implication for beta-cell function is not known.To determine whether increased beta cell glucagon receptor expression and action influences multiple aspe... |
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GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis.
Diabetes 63(12) , 4197-205, (2014) γ-Aminobutyric acid (GABA) exerts protective and regenerative effects on mouse islet β-cells. However, in humans it is unknown whether it can increase β-cell mass and improve glucose homeostasis. To address this question, we transplanted a suboptimal mass of ... |
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[Endocrinological aspects of diabetes mellitus in the elderly].
Nihon Rinsho. 71(11) , 1941-7, (2013) Glucose-mediated energy production in central nervous system(CNS) reduces in the elderly. The reduction is also observed in young patients with diabetes mellitus(DM). Deviated endocrinological function is observed in both the elderly and young patients with D... |