FEBS Letters 1992-01-01

Lipopolysaccharide impairs hepatocyte ureagenesis from ammonia: Involvement of mitochondrial aquaporin-8

Leandro R. Soria, Julieta Marrone, Sara M. Molinas, Guillermo L. Lehmann, Giuseppe Calamita, Raúl A. Marinelli

Index: FEBS Lett. 588(9) , 1686-91, (2014)

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Abstract

• Lipopolysaccharide down-regulates hepatocyte mitochondrial aquaporin-8 expression. • Lipopolysaccharide decreases mitochondrial ammonia diffusional permeability. • Lipopolysaccharide impairs hepatocyte ureagenesis from ammonia. • A role for aquaporin-8 in defective hepatic ammonia removal in sepsis is suggested.