Cefpodoxime Proxetil
Cefpodoxime Proxetil structure
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Common Name | Cefpodoxime Proxetil | ||
|---|---|---|---|---|
| CAS Number | 87239-81-4 | Molecular Weight | 557.597 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H27N5O9S2 | Melting Point | 111-113°C | |
| MSDS | N/A | Flash Point | N/A | |
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A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis.
J. Indian Med. Assoc. 110(8) , 580-3, (2012) Tonsillitis causes considerable short and medium term morbidity, and can be recurrent. Sinusitis can be acute (less than 4 weeks), subacute (4-8 weeks) or chronic (8 weeks or more). To study the comparative efficacy and safety of multidose treatments of linco... |
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Ionic liquids as superior solvents for headspace gas chromatography of residual solvents with very low vapor pressure, relevant for pharmaceutical final dosage forms.
J. Chromatogr. A. 1216(32) , 6020-3, (2009) 1-n-Butyl-3-methylimidazolium dimethyl phosphate (BMIM DMP) was identified as the most suitable ionic liquid as solvent for the headspace gas chromatographic analysis of solvents with very low vapor pressure such as dimethylsulfoxide, N-methylpyrrolidone, sul... |
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Cefpodoxime proxetil. An appraisal of its use in antibacterial cost-containment programmes, as stepdown and abbreviated therapy in respiratory tract infections.
Pharmacoeconomics 10(2) , 164-78, (1996) Cefpodoxime proxetil is an orally administered prodrug which is converted in vivo to the third generation cephalosporin cefpodoxime. Cefpodoxime has a similar spectrum of antibacterial activity to the parenteral cephalosporins ceftriaxone and cefotaxime and a... |
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An efficient one-pot reaction for selective fluorimetric determination of cefpodoxime and its prodrug.
Talanta 85(4) , 2121-7, (2011) Cefpodoxime proxetil (CFP), an oral third-generation cephalosporin, is a prodrug that is de-esterified in vivo to its active metabolite, cefpodoxime acid (CFA). Therefore, this study aimed to develop a facile and efficient one-pot reaction for selective and s... |
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Simultaneous quantification of cefpodoxime proxetil and clavulanic acid in human plasma by LC-MS using solid phase extraction with application to pharmacokinetic studies.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 921-922 , 49-55, (2013) A simple, rapid and selective high performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (HPLC-APCI-MS) method was developed and validated for the simultaneous estimation of cefpodoxime proxetil (CDPX) and clavulanic aci... |
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Self-nanoemulsifying drug delivery system of cefpodoxime proxetil containing tocopherol polyethylene glycol succinate.
Drug Dev. Ind. Pharm. 39(5) , 635-45, (2013) Lipid based drug delivery systems have gained prominence in last decade for drugs with dissolution rate limited oral bioavailability.To improve the solubility, permeability and oral bioavailability of cefpodoxime proxetil, β-lactam antibiotic. It is BCS Class... |
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Comparison of cefpodoxime proxetil release and antimicrobial activity from tablet formulations: complexation with hydroxypropyl-β-cyclodextrin in the presence of water soluble polymer.
Drug Dev. Ind. Pharm. 38(6) , 689-96, (2012) This study aims to prove the complexation of cefpodoxime proxetil (CP) by hydroxypropyl-β-cyclodextrin (HP-β-CD) in the presence of sodium carboxymethyl cellulose (Na CMC), and makes a comparison of commercial tablets by dissolution and antimicrobial activity... |
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Enhancement of bioavailability of cefpodoxime proxetil using different polymeric microparticles.
AAPS PharmSciTech 11(3) , 1368-75, (2010) Poorly water-soluble drugs such as cefpodoxime proxetil (400 μg/ml) offer a challenging problem in drug formulation as poor solubility is generally associated with poor dissolution characteristics and thus poor oral bioavailability. According to these charact... |
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Verification of cefmetazole and cefpodoxime proxetil contamination to other pharmaceuticals by liquid chromatography-tandem mass spectrometry.
Chem. Pharm. Bull. 54(10) , 1469-72, (2006) Cross-contamination is a critical issue for pharmaceutical manufacturing, especially for beta-lactam antibiotics. Thus, an analytical method for the simultaneous determination of beta-lactam antibiotics cefmetazole (CMZ) and cefpodoxime proxetil (CPDXPR) cont... |
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Cefpodoxime proxetil compared with cefixime for treatment of typhoid fever in children.
Indian Pediatr. 44(11) , 838-41, (2007) In order to evaluate clinical and bacteriological efficacy of Cefpodoxime Proxetil (CP) in typhoid fever in comparison to cefixime (CF), we assessed 140 children with suspected typhoid fever. Fulfilling inclusion criteria finally 40 culture confirmed typhoid ... |