Phenyl-vinylsulfon
Phenyl-vinylsulfon structure
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Common Name | Phenyl-vinylsulfon | ||
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| CAS Number | 5535-48-8 | Molecular Weight | 168.213 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 314.4±15.0 °C at 760 mmHg | |
| Molecular Formula | C8H8O2S | Melting Point | 67-69 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 178.6±13.1 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Fasciola gigantica: evaluation of the effect of phenyl vinyl sulfone in vitro.
Exp. Parasitol. 119(1) , 125-34, (2008) Phenyl vinyl sulfone is a synthetic inhibitor of cysteine protease and has antihelminthic and antiprotozoal properties. Phenyl vinyl sulfone was assayed in vitro for antifasciola activity against adult Fasciola gigantica worms using a well-established culture... |
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Sortase inhibitor phenyl vinyl sulfone inhibits Renibacterium salmoninarum adherence and invasion of host cells.
Dis. Aquat. Organ. 78(2) , 115-27, (2007) Renibacterium salmoninarum, the causative agent of bacterial kidney disease in salmonid fishes, is a Gram-positive diplococcobacillus belonging to the family Micrococcaceae. Analysis of the genome sequence of the bacterium demonstrated the presence of a sorta... |
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Catalytic enantioselective reduction of beta,beta-disubstituted vinyl phenyl sulfones by using bisphosphine monoxide ligands.
Angew. Chem. Int. Ed. Engl. 46(31) , 5955-7, (2007)
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Prediction of systemic concentrations of sensitizing compound using TKTD simulation model.
Environ. Sci. 12(6) , 371-9, (2005) To investigate the safe handling of an industrial product, phenyl vinyl sulfone (PVS), which has an extremely high potential for dermal sensitization at low concentrations and positive mutagenicity, the maximum no-effect concentration for dermal deposits was ... |
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Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases.
J. Am. Chem. Soc. 130(26) , 8251-60, (2008) Protein tyrosine phosphatases (PTPs) play key roles in the regulation of normal and pathological processes ranging from cell proliferation, differentiation, metabolism, and survival to many human diseases including cancer and diabetes. Functional studies of P... |
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Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.
J. Biol. Chem. 284(39) , 26839-50, (2009) The protozoan parasite Toxoplasma gondii relies on post-translational modification, including proteolysis, of proteins required for recognition and invasion of host cells. We have characterized the T. gondii cysteine protease cathepsin L (TgCPL), one of five ... |
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Close-up of mushroom-shaped fibrillar adhesive microstructure: contact element behaviour.
J. R. Soc. Interface 5(24) , 785-9, (2008) To analyse the performance of mushroom-shaped fibrillar adhesive microstructure, its behaviour was studied during different stages of attachment-loading-detachment cycle. Visualizing the evolutions of real contact area of single microfibres, it is shown that ... |
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Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform.
Bioorg. Med. Chem. 17 , 2886-93, (2009) cis-5-Phenyl prolinates with electrophilic substituents at the fourth position of a pyrrolidine ring were synthesized by 1,3-dipolar cycloaddition of arylimino esters with divinyl sulfone and acrylonitrile. 4-Vinylsulfonyl 5-phenyl prolinates inhibit Staphylo... |
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Addition to electron deficient olefins of alpha-oxy carbon- centered radicals, generated from cyclic ethers and acetals by the reaction with alkylperoxy- lambda(3)-iodane.
Molecules 10(1) , 195-200, (2005) Thermal decomposition of 1-tert-butylperoxy-1,2-benziodoxol-3(1H)-one in cyclic ethers and acetals at 50 degrees C generates alpha-oxy carbon-centered radicals, which undergo an addition reaction with vinyl sulfones and unsaturated esters. |
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Tetrahedron Lett. 34 , 7583, (1993)
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