Orphenadrine hydrochloride
Orphenadrine hydrochloride structure
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Common Name | Orphenadrine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 341-69-5 | Molecular Weight | 305.84200 | |
| Density | 1.014g/cm3 | Boiling Point | 363ºC at 760mmHg | |
| Molecular Formula | C18H24ClNO | Melting Point | 156 - 157ºC | |
| MSDS | Chinese USA | Flash Point | 107.1ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs.
Exp. Neurol. 255 , 96-102, (2014) Although the sodium channel blocker mexiletine is considered the first-line drug in myotonia, some patients experiment adverse effects, while others do not gain any benefit. Other antimyotonic drugs are thus needed to offer mexiletine alternatives. In the pre... |
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Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study.
Audiol. Neurootol. 17(3) , 179-88, (2012) Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study ... |
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Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.
Naunyn Schmiedebergs Arch. Pharmacol. 376(4) , 275-84, (2007) The anticholinergic antiparkinson drug orphenadrine is an antagonist at central and peripheral muscarinic receptors. Orphenadrine intake has recently been linked to QT prolongation and Torsade-de-Pointes tachycardia. So far, inhibitory effects on I (Kr) or cl... |
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Validated stability-indicating reversed-phase-HPLC method for simultaneous determination of orphenadrine citrate, caffeine and aspirin.
Chem. Pharm. Bull. 60(11) , 1426-36, (2012) New, simple, rapid and precise reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of orphenadrine citrate, caffeine and aspirin in presence of aspirin degradation products, orphenadrine citrate and c... |
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Pharmacokinetic, metabolism and withdrawal time of orphenadrine in camels (Camelus dromedarius) after intravenous administration.
Res. Vet. Sci. 85(3) , 563-9, (2008) The pharmacokinetics of orphenadrine (ORPH) following a single intravenous (i.v.) dose was investigated in six camels (Camelus dormedarius). Orphenadrine was extracted from the plasma using a simple sensitive liquid-liquid extraction method and determined by ... |
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Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.
J. Pharm. Pharmacol. 61(1) , 47-54, (2009) It has been reported that the non-renal clearance of furosemide was significantly faster in rats pretreated with phenobarbital but was not altered in rats pretreated with 3-methylcholanthrene. However, no studies on other cytochrome P450 (CYP) isozymes have y... |
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Influence of orphenadrine upon the protective activity of various antiepileptics in the maximal electroshock-induced convulsions in mice.
Pharmacol. Rep. 61(4) , 732-6, (2009) Orphenadrine is an anticholinergic drug used in the treatment of Parkinson's disease, and is also known to exert nonspecific antagonistic activity at the phencyclidine binding site of the N-methyl-D-aspartate (NMDA) receptor. The aim of this study was to asse... |
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Anticholinergic drug-induced delirium in an elderly Alzheimer's dementia patient.
Arch. Gerontol. Geriatr. 44 Suppl 1 , 199-206, (2007) Drug-induced delirium is a common matter in the elderly and anticholinergics, together with a number of different drugs, may significantly contribute to the delirium onset, especially in demented people. We report a case of a probable anticholinergic drug-ind... |
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Orphenadrine induces secondarily generalized convulsive status epilepticus in rats.
Brain Res. Bull. 84(6) , 389-93, (2011) The current study was aimed to assess the convulsant potency of orphenadrine (ORPH) in rats together with a screen of different conventional antiepileptic drugs (AEDs) on their efficacy to suppress it. ORPH was administered intraperitoneally (i.p.) in doses o... |
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Vibrational spectra and density functional theoretical calculations on the anti-neurodegenerative drug: Orphenadrine hydrochloride.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97 , 838-46, (2012) Vibrational spectral analysis and quantum chemical computations based on density functional theory have been performed on the anti-neuro-degenerative drug Orphenadrine hydrochloride. The geometry, intermolecular hydrogen bond, and harmonic vibrational frequen... |