U-73343
U-73343 structure
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Common Name | U-73343 | ||
|---|---|---|---|---|
| CAS Number | 142878-12-4 | Molecular Weight | 466.66 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 641.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C29H42N2O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 341.8±31.5 °C | |
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Mechanisms of the sarcoplasmic reticulum Ca2+ release induced by P2X receptor activation in mesenteric artery myocytes.
Pharmacol. Rep. 66(3) , 363-72, (2014) ATP is one of the principal sympathetic neurotransmitters which contracts vascular smooth muscle cells (SMCs) via activation of ionotropic P2X receptors (P2XRs). We have recently demonstrated that contraction of the guinea pig small mesenteric arteries evoked... |
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G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels.
Pflugers Arch. 466(8) , 1635-46, (2014) TRPC5 is an ion channel permeable to monovalent and divalent cations that is widely expressed in different tissues. Although implicated in the control of neurite extension and in the growth cone morphology of hippocampal neurons, as well as in fear-related be... |
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Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
Eur. J. Pharmacol. 514(2-3) , 151-8, (2005) Bombesin receptors are mainly divided into two subtypes: BB1 receptor (neuromedin B-preferring receptor) and BB2 receptor [gastrin-releasing peptide (GRP)-preferring receptor]. Previously, we reported that intracerebroventricularly (i.c.v.) administered bombe... |
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Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability.
J. Physiol. 572(Pt 2) , 359-77, (2006) TRPC6 is thought to be a Ca(2+)-permeable cation channel activated following stimulation of G-protein-coupled membrane receptors linked to phospholipase C (PLC). TRPC6 current is also activated by exogenous application of 1-oleoyl-acetyl-sn-glycerol (OAG) or ... |
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Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta.
Am. J. Physiol. Heart Circ. Physiol. 290(1) , H37-45, (2006) ACh stimulates arachidonic acid (AA) release from membrane phospholipids of vascular endothelial cells (ECs). In rabbit aorta, AA is metabolized through the 15-lipoxygenase pathway to form vasodilatory eicosanoids 15-hydroxy-11,12-epoxyeicosatrienoic acid (HE... |
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P2Y4-mediated regulation of Na+ absorption in the Reissner's membrane of the cochlea.
J. Neurosci. 30 , 3762-9, (2010) The epithelial cells of Reissner's membrane (RM) are capable of transporting Na(+) out of endolymph via epithelial Na(+) channel (ENaC). However, much remains to be known as to mechanism of regulation of Na(+) absorption in RM. We investigated P2Y signaling a... |
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Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.
J. Pharmacol. Exp. Ther. 255 , 756, (1990) Aggregation of human platelets induced by a variety of agonists was inhibited by 1-[6-[[17 beta-3-methoxyestra-1,3,5(10)-trien-17-yl] amino]hexyl]-1H-pyrrole-2,5-dionel (U-73122) (IC50 values 1-5 microM), but not by the close analog 1-[6-[[17 beta-3-methoxyes... |
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Effects of pilocarpine on the secretory acinar cells in human submandibular glands.
Life Sci. 79(26) , 2441-7, (2006) Pilocarpine has been used as a choice of drugs for treatment of impaired salivary flow. Although considerable data are available as to the stimulatory effect of pilocarpine on the salivary secretion in human, its underlying mechanism, at the cellular level, h... |
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Involvement of phospholipase C and intracellular calcium signaling in the gonadotropin-releasing hormone regulation of prolactin release from lactotrophs of tilapia (Oreochromis mossambicus).
Gen. Comp. Endocrinol. 142(1-2) , 227-33, (2005) Gonadotropin-releasing hormone (GnRH) is a potent stimulator of prolactin (PRL) secretion in various vertebrates including the tilapia, Oreochromis mossambicus. The mechanism by which GnRH regulates lactotroph cell function is poorly understood. Using the adv... |
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Inhibition of phospholipase C-independent exocytotic responses in rat peritoneal mast cells by U73122.
Regul. Pept. 125(1-3) , 179-84, (2005) The aminosteroid U73122 has been established as potent, selective, and cell-permeable inhibitor C-type phosphatidylinositol-specific phospholipases (PI-PLCs), and has been used to define a contribution of PI-PLCs as part of exocytotic signalling pathways in r... |