hexaethyleneglycol
hexaethyleneglycol structure
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Common Name | hexaethyleneglycol | ||
|---|---|---|---|---|
| CAS Number | 2615-15-8 | Molecular Weight | 282.331 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 378.3±0.0 °C at 760 mmHg | |
| Molecular Formula | C12H26O7 | Melting Point | 5-7 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 193.7±26.5 °C | |
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Synthesis and evaluation of new spacers for use as dsDNA end-caps.
Bioconjug. Chem. 21(8) , 1545-53, (2010) A series of aliphatic and aromatic spacer molecules designed to cap the ends of DNA duplexes have been synthesized. The spacers were converted into dimethoxytrityl-protected phosphoramidites as synthons for oligonucleotides synthesis. The effect of the spacer... |
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Adsorption isotherms of aqueous C12E6 and cetyltrimethylammonium bromide surfactants on solid surfaces in the presence of low molecular weight coadsorbents.
Langmuir 25(10) , 5536-44, (2009) In this work, we evaluate the effects of the low molecular weight compounds toluene, phenol, and 1-hexanol on the adsorption of two surfactants on one solid surface. The surfactants are cetyltrimethylammonium bromide (CTAB, cationic) and hexaethylene glycol m... |
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A nicked duplex decamer DNA with a PEG(6) tether.
Nucleic Acids Res. 29(5) , 1132-43, (2001) A dumbbell double-stranded DNA decamer tethered with a hexaethylene glycol linker moiety (DDSDPEG), with a nick in the centre of one strand, has been synthesised. The standard NMR methods, E.COSY, TOCSY, NOESY and HMQC, were used to measure (1)H, (31)P and T:... |
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Design and synthesis of RNA miniduplexes via a synthetic linker approach.
Biochemistry 32(7) , 1751-8, (1993) Double-stranded oligodeoxyribonucleotides or single-stranded oligoribonucleotides with specific secondary structure have been proposed as potential antagonists to target nucleic acid-binding proteins (the sense approach). A major limitation of this strategy i... |
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Selectively 13C-enriched DNA: 13C and 1H assignments of a triple helix by two-dimensional relayed HMQC experiments.
J. Biomol. NMR 4(4) , 575-80, (1994) We present NMR studies of an intramolecular triple helix, the three strands of which have been linked by a hexaethylene glycol chain. To overcome the generally encountered difficulties of assignment in the homo-pyrimidine strands, the carbon Cl' of the pyrimi... |
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Solid-phase PCR in microwells: effects of linker length and composition on tethering, hybridization, and extension.
Biotechniques 32(2) , 410, 412, 414-8, 420, (2002) During the solid-phase PCR (SP-PCR), DNA oligonucleotides complementary to a soluble template and immobilized on a surface are extended in situ. Although primarily used for pathogen detection, SP-PCR has the potential for much broader application, including d... |
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Template-directed ligation of tethered mononucleotides by t4 DNA ligase for kinase ribozyme selection.
PLoS ONE 5(8) , e12368, (2010) In vitro selection of kinase ribozymes for small molecule metabolites, such as free nucleosides, will require partition systems that discriminate active from inactive RNA species. While nucleic acid catalysis of phosphoryl transfer is well established for pho... |
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Distamycin A complexation with a nucleic acid triple helix.
Biochemistry 35(28) , 9133-9, (1996) The interaction of the minor groove binding drug distamycin with the T-A-T triple helix and the A-T double helix was studied using circular dichroism spectroscopy and thermal denaturation. The triple helix was made by the oligonucleotide (dA)12-x-(dT)12-x-(dT... |
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Secondary binding sites for triplex-forming oligonucleotides containing bulges, loops, and mismatches in the third strand.
Biochemistry 39(22) , 6714-25, (2000) We have used DNase I footprinting to examine the binding of five different 17-mer oligonucleotides to a 53-base oligopurine tract containing four pyrimidine interruptions. Although all the expected triplexes formed with high affinity (K(d) approximately 10-50... |
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Synthesis of a cholesteryl-HEG phosphoramidite derivative and its application to lipid-conjugates of the anti-HIV 5'TGGGAG³' Hotoda's sequence.
Molecules 17(10) , 12378-92, (2012) A novel phosphoramidite derivative of cholesterol, with an ether-linked hexaethylene glycol (HEG) spacer arm, has been obtained through simple and reproducible solid phase modified oligonucleotide synthesis manipulations. This building block and the known pho... |