S-(LACTOYL)GLUTATHIONE
S-(LACTOYL)GLUTATHIONE structure
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Common Name | S-(LACTOYL)GLUTATHIONE | ||
|---|---|---|---|---|
| CAS Number | 54398-03-7 | Molecular Weight | 377.37 | |
| Density | 1.469g/cm3 | Boiling Point | 772.1ºC at 760 mmHg | |
| Molecular Formula | C13H19N3O8S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 420.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis.
Free Radic. Res. 48(7) , 729-39, (2014) Methylglyoxal (MG) is a precursor of advanced glycation end products, which contribute to diabetic complications, including bone defects. In the present study, the effect of sciadopitysin on MG-induced cytotoxicity was investigated using osteoblastic MC3T3-E1... |
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Converting GLX2-1 into an active glyoxalase II.
Biochemistry 49 , 8228-8236, (2010) Arabidopsis thaliana glyoxalase 2-1 (GLX2-1) exhibits extensive sequence similarity with GLX2 enzymes but is catalytically inactive with SLG, the GLX2 substrate. In an effort to identify residues essential for GLX2 activity, amino acid residues were altered a... |
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The binding of iron and zinc to glyoxalase II occurs exclusively as di-metal centers and is unique within the metallo-beta-lactamase family.
J. Biol. Inorg. Chem. 9 , 429-438, (2004) Cytosolic glyoxalase 2 (GLX2-2) from Arabidopsis thaliana is a metalloenzyme that has been shown to bind a mixture of Zn, Fe, or Mn when produced in cells grown in rich media. In an effort to prepare metal-enriched samples, GLX2-2 was over-expressed in minima... |
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The critical role of S-lactoylglutathione formation during methylglyoxal detoxification in Escherichia coli.
Mol. Microbiol. 78 , 1577-1590, (2010) Survival of exposure to methylglyoxal (MG) in Gram-negative pathogens is largely dependent upon the operation of the glutathione-dependent glyoxalase system, consisting of two enzymes, GlxI (gloA) and GlxII (gloB). In addition, the activation of the KefGB pot... |
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Inhibition of human leukaemia 60 cell growth by S-D-lactoylglutathione in vitro. Mediation by metabolism to N-D-lactoylcysteine and induction of apoptosis.
Leuk. Res. 20 , 17-26, (1996) The inhibition of human leukaemia 60 cell growth by S-D-lactoylglutathione in vitro is mediated by the inhibtion of de novo pyridimine synthesis. When S-D-lactoylglutathione was added to human leukaemia 60 cells in culture, it was hydrolysed by thiolesterase ... |
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Characterization of the glyoxalase I gene from the vascular wilt fungus Verticillium dahliae.
Can. J. Microbiol. 52 , 816-822, (2006) A glyoxalase I gene homologue (VdGLO1) was identified in the vascular wilt fungus Verticillium dahliae by sequence tag analysis of genes expressed during resting structure development. The results of the current study show that the gene encodes a putative 345... |
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Metabolic engineering of glyoxalase pathway for enhancing stress tolerance in plants.
Methods Mol. Biol. 639 , 95-118, (2010) Glyoxalase system consists of two enzymes glyoxalase I (Gly I) and glyoxalase II (Gly II). Gly I detoxifies methylglyoxal (MG), a cytotoxic byproduct of glycolysis, to S-lactoylglutathione (SLG) where it uses one molecule of reduced glutathione. Subsequently,... |
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Substrate specificity of bovine liver formaldehyde dehydrogenase.
J. Biol. Chem. 261(30) , 14240-4, (1986) Formaldehyde dehydrogenases isolated from several different biological sources have been reported to catalyze the NAD+-dependent oxidative acylation of glutathione by methylglyoxal to form S-pyruvylglutathione, suggesting the involvement of this enzyme in the... |