3,3'-diaminobenzidine

3,3'-diaminobenzidine Structure
3,3'-diaminobenzidine structure
Common Name 3,3'-diaminobenzidine
CAS Number 91-95-2 Molecular Weight 214.266
Density 1.3±0.1 g/cm3 Boiling Point 481.7±45.0 °C at 760 mmHg
Molecular Formula C12H14N4 Melting Point 175-177 °C(lit.)
MSDS Chinese USA Flash Point 282.7±25.6 °C
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger

Nerve demyelination increases metabotropic glutamate receptor subtype 5 expression in peripheral painful mononeuropathy.

Int. J. Mol. Sci. 16(3) , 4642-65, (2015)

Wallerian degeneration or nerve demyelination, arising from spinal nerve compression, is thought to bring on chronic neuropathic pain. The widely distributed metabotropic glutamate receptor subtype 5 (mGluR5) is involved in modulating nociceptive transmission...

Proteomic analysis in serum of rat hind-limb allograft tolerance induced by immunosuppressive therapy with adipose-derived stem cells.

Plast. Reconstr. Surg. 134(6) , 1213-23, (2014)

Adipose-derived stem cells combined with transient immunosuppression prolonged vascularized composite tissue allotransplant survival and induced immune tolerance in a rodent hind-limb model. The authors investigated serum proteins in the adipose-derived stem ...

Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.

PLoS ONE 10(3) , e0119423, (2015)

Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in n...

Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells.

Biochim. Biophys. Acta 1853(2) , 377-87, (2015)

Macroautophagy (autophagy) is an important factor affecting the function of vascular endothelial cells (VECs) and must be tightly regulated in these cells. However, the precise mechanisms underlying this process, particularly in the presence of serum, remain ...

The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.

J. Ethnopharmacol. 168 , 268-78, (2015)

Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced ex...

Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells.

Oncol. Lett. 8(5) , 1993-1999, (2014)

Obesity, diabetes and insulin resistance are marked risk factors that promote the development of type I endometrial cancer. Previous studies have demonstrated that insulin-like growth factor 1 (IGF-1) and IGF-2 promote cell proliferation in endometrial cancer...

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine.

J. Neurovirol. 21(2) , 159-73, (2015)

Recovery from encephalomyelitis induced by infection with mosquito-borne alphaviruses is associated with a high risk of lifelong debilitating neurological deficits. Infection of mice with the prototypic alphavirus, Sindbis virus, provides an animal model with...

Live attenuated African swine fever viruses as ideal tools to dissect the mechanisms involved in viral pathogenesis and immune protection.

Vet. Res. 46 , 135, (2015)

African swine fever virus (ASFV) is the causal agent of African swine fever, a hemorrhagic and often lethal porcine disease causing enormous economical losses in affected countries. Endemic for decades in most of the sub-Saharan countries and Sardinia, the ri...

Involvement of adiponectin in the pathogenesis of dystrophinopathy.

Skelet. Muscle 5 , 25, (2015)

The hormone adiponectin (ApN) is decreased in the metabolic syndrome, where it plays a key pathogenic role. ApN also exerts some anti-inflammatory effects on skeletal muscles in mice exposed to acute or chronic inflammation. Here, we investigate whether ApN c...

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma.

Sci. Signal. 8 , ra82, (2015)

Most patients with BRAF-mutant metastatic melanoma display remarkable but incomplete and short-lived responses to inhibitors of the BRAF kinase or the mitogen-activated protein kinase kinase (MEK), collectively BRAF/MEK inhibitors. We found that inherent resi...