Methoxyphenamine hydrochloride
Methoxyphenamine hydrochloride structure
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Common Name | Methoxyphenamine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 5588-10-3 | Molecular Weight | 215.720 | |
| Density | 0.951 g/cm3 | Boiling Point | 252.3ºCat 760 mmHg | |
| Molecular Formula | C11H18ClNO | Melting Point | 210°C | |
| MSDS | Chinese USA | Flash Point | 102.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Quinidine but not quinine inhibits in man the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.
Eur. J. Clin. Pharmacol. 41(5) , 471-4, (1991) Healthy male volunteers (n = 13) took a single oral dose of 60.3 mg of methoxyphenamine HCl with and without prior administration of either quinidine (250 mg as bisulphate salt) or its diastereomer quinine (300 mg as sulphate salt). Methoxyphenamine and its N... |
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Influence of urinary pH on the disposition of methoxyphenamine and three metabolites in humans.
J. Pharm. Sci. 76(6) , 427-32, (1987) The disposition of methoxyphenamine (o-methoxy-N,alpha-dimethylphenethylamine) and three of its metabolites was studied in five healthy volunteers on three occasions, with the urine pH separately under uncontrolled, acidic, and basic conditions. All five volu... |
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Metabolism of methoxyphenamine and 2-methoxyamphetamine in P4502D6-transfected cells and cell preparations.
Xenobiotica 25(9) , 895-906, (1995) 1. Control and P4502D6-transfected human B-lymphoblastoid cell lines (cHol and h2D6v2 respectively) were used to study 2D6-mediated metabolism of methoxyphenamine (MPA) and 2-methoxyamphetamine (2MA). The main metabolites were products of O-dealkylation and a... |
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Effect of sparteine and quinidine on the metabolism of methoxyphenamine by Cunninghamella bainieri.
Xenobiotica 19(4) , 445-52, (1989) 1. The fungus C. bainieri, incubated for 7 days with methoxyphenamine alone or in combination with either sparteine or quinidine, gave N-desmethylmethoxyphenamine and its N-acetyl conjugate as major metabolites, while O-desmethylmethoxyphenamine, 5-hydroxymet... |
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Efficacy and safety of modified sequential three-step empirical therapy for chronic cough.
Respirology 15(5) , 830-6, (2010) Sequential three-step empirical therapy is useful for the management of chronic cough. The purpose of this study was to evaluate the efficacy and safety of modified sequential three-step empirical therapy.Consecutive patients (n = 240) with chronic cough were... |
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Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.
Xenobiotica 21(11) , 1441-50, (1991) 1. Lewis rats (n = 7 or 8) were dosed with methoxyphenamine with and without prior administration of various doses of either quinine or its diastereomer quinidine. Methoxyphenamine and its N-desmethyl, O-desmethyl and aromatic 5-hydroxy metabolites were quant... |
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Anti-inflammatory effect of methoxyphenamine compound in rat model of chronic obstructive pulmonary disease.
Acta Pharmacol. Sin. 24(12) , 1324-7, (2003) To evaluate the anti-inflammatory effect of methoxyphenamine compound (MC) on chronic obstructive pulmonary disease (COPD) in rats by measurement of proinflammatory cytokines, total and differential white cell counts (WCC) of bronchroalveolar lavage fluid (BA... |
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Doping control analysis of methoxyphenamine using liquid chromatography-tandem mass spectrometry.
Eur. J. Mass Spectrom. (Chichester, Eng.) 14(3) , 145-52, (2008) Methoxyphenamine (o-methoxy-N,alpha-dimethylphenethylamine, Orthoxine) used in earlier times as a bronchodilator is prohibited in sports according to the regulations of the World Anti-Doping Agency (WADA). The drug and several of its metabolites are commonly ... |
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Kinetics of in vitro metabolism of methoxyphenamine in rats.
Xenobiotica 20(1) , 55-70, (1990) 1. Methoxyphenamine (MP) was metabolized in vitro by rat liver preparations to O-desmethylmethoxyphenamine (O-desmethyl-MP), N-desmethylmethoxyphenamine (N-desmethyl-MP) and 5-hydroxymethoxyphenamine (5-hydroxy-MP). These metabolic pathways were inhibited by ... |
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The influence of pregnancy on the biotransformation and urinary excretion of methoxyphenamine in mice.
Biopharm. Drug Dispos. 16(1) , 1-11, (1995) (i) The urinary elimination of methoxyphenamine (MPA) and its metabolites in underivatized samples was examined after single and multiple oral administration to pregnant and non-pregnant mice by GLC and GLC-MS. (ii) The major metabolite O-desmethylmethoxyphen... |