Mandelonitrile
Mandelonitrile structure
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Common Name | Mandelonitrile | ||
|---|---|---|---|---|
| CAS Number | 532-28-5 | Molecular Weight | 133.147 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 282.7±20.0 °C at 760 mmHg | |
| Molecular Formula | C8H7NO | Melting Point | -10 °C | |
| MSDS | Chinese USA | Flash Point | 97.2±0.0 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Protein engineering of a nitrilase from Burkholderia cenocepacia J2315 for efficient and enantioselective production of (R)-o-chloromandelic acid.
Appl. Environ. Microbiol. 81 , 8469-77, (2015) The nitrilase-mediated pathway has significant advantages in the production of optically pure aromatic α-hydroxy carboxylic acids. However, low enantioselectivity and activity are observed on hydrolyzing o-chloromandelonitrile to produce optically pure (R)-o-... |
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Metabolites of amygdalin under simulated human digestive fluids.
Int. J. Food Sci. Nutr. 61(8) , 770-9, (2010) In the present study, degradation of amygdalin in the human digestive fluids and absorption of its metabolites by the human small intestine were evaluated by simulating a gastrointestinal digestion model combined with a human intestinal cell culture. Orally a... |
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Hydroxynitrile lyase catalysis in ionic liquid-containing systems.
Biotechnol. Lett. 27(18) , 1387-90, (2005) The cleavage of mandelonitrile catalysed by hydroxynitrile lyases (HNL) from Prunus amygdalus (PaHNL) and Manihot esculenta (MeHNL) proceeded more rapidly in monophasic aqueous media containing 1-propyl-3-methylimidazolium tetrafluoroborate [C4MIm][BF4] than ... |
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Screening for new hydroxynitrilases from plants.
Biosci. Biotechnol. Biochem. 69 , 2349-57, (2005) We established a simple HPLC method to determine the activity and stereochemistry of the chiral mandelonitrile synthesized from benzaldehyde and cyanide, and applied it to screen for hydroxynitrile lyase (HNL) activity of plant origin. A total of 163 species ... |
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Utilization of arylaliphatic nitriles by haloalkaliphilic Halomonas nitrilicus sp. nov. isolated from soda soils.
Appl. Microbiol. Biotechnol. 81(2) , 371-8, (2008) An enrichment culture from saline soda soils, using acetate as carbon and energy source and 2-phenylpropionitrile as nitrogen source (PPN) at pH 10, resulted in the isolation of strain ANL-alpha CH3. The strain was identified as a representative of the genus ... |
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Identification of amino acid residues responsible for the enantioselectivity and amide formation capacity of the Arylacetonitrilase from Pseudomonas fluorescens EBC191.
Appl. Environ. Microbiol. 75(17) , 5592-9, (2009) The nitrilase from Pseudomonas fluorescens EBC191 converted (R,S)-mandelonitrile with a low enantioselectivity to (R)-mandelic acid and (S)-mandeloamide in a ratio of about 4:1. In contrast, the same substrate was hydrolyzed by the homologous nitrilase from A... |
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Biochemical and structural characterization of a novel bacterial manganese-dependent hydroxynitrile lyase.
FEBS J. 280(22) , 5815-28, (2013) Hydroxynitrile lyases (HNLs), which catalyse the decomposition of cyanohydrins, are found mainly in plants. In vitro, they are able to catalyse the synthesis of enantiopure cyanohydrins, which are versatile building blocks in the chemical industry. Recently, ... |
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Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha/beta-hydrolase fold.
J. Biotechnol. 141(3-4) , 166-73, (2009) Hydroxynitrile lyases (HNLs) are applied in technical processes for the synthesis of chiral cyanohydrins. Here we describe the thorough characterization of the recently discovered R-hydroxynitrile lyase from Arabidopsis thaliana and its S-selective counterpar... |
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Comprehensive step-by-step engineering of an (R)-hydroxynitrile lyase for large-scale asymmetric synthesis.
Angew. Chem. Int. Ed. Engl. 42(39) , 4815-4818, (2003)
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Laboratory evolved biocatalysts for stereoselective syntheses of substituted benzaldehyde cyanohydrins.
ChemBioChem. 9(1) , 58-61, (2008)
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