2,6-Difluorobenzenesulfonamide
2,6-Difluorobenzenesulfonamide structure
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Common Name | 2,6-Difluorobenzenesulfonamide | ||
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| CAS Number | 60230-37-7 | Molecular Weight | 193.171 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 309.2±52.0 °C at 760 mmHg | |
| Molecular Formula | C6H5F2NO2S | Melting Point | 187-191 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 140.8±30.7 °C | |
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Factors influencing the CNS distribution of a novel MEK-1/2 inhibitor: implications for combination therapy for melanoma brain metastases.
Drug Metab. Dispos. 42(8) , 1292-300, (2014) Brain metastases are a major cause of mortality in patients with advanced melanoma. Adequate brain distribution of targeted agents for melanoma will be critical for treatment success. Recently, improvement in overall survival led to US Food and Drug Administr... |
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Thermodynamic parameters for the association of fluorinated benzenesulfonamides with bovine carbonic anhydrase II.
Chem. Asian J. 2(1) , 94-105, (2007) This paper describes a calorimetric study of the association of a series of seven fluorinated benzenesulfonamide ligands (C6H(n)F(5-n)SO2NH2) with bovine carbonic anhydrase II (BCA). Quantitative structure-activity relationships between the free energy, entha... |
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Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases.
J. Pharmacol. Exp. Ther. 356 , 251-9, (2016) Small molecule inhibitors targeting the mitogen-activated protein kinase pathway (Braf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase) have had success in extending survival for patients with metastatic melanoma. Unfortunately, ... |
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Insect growth regulators. Analogs of TH-6038 and TH-6040. Oliver JE, et al.
J. Agric. Food Chem. 24(5) , 1065-1068, (1976)
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