Octanoic acid, 2-bromo-
Octanoic acid, 2-bromo- structure
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Common Name | Octanoic acid, 2-bromo- | ||
|---|---|---|---|---|
| CAS Number | 2623-82-7 | Molecular Weight | 223.10700 | |
| Density | 1.278 g/mL at 25 °C(lit.) | Boiling Point | 140 °C5 mm Hg(lit.) | |
| Molecular Formula | C8H15BrO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | >230 °F | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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Accumulation of polyhydroxyalkanoic acid containing large amounts of unsaturated monomers in Pseudomonas fluorescens BM07 utilizing saccharides and its inhibition by 2-bromooctanoic acid.
Appl. Environ. Microbiol. 67(11) , 4963-74, (2001) A psychrotrophic bacterium, Pseudomonas fluorescens BM07, which is able to accumulate polyhydroxyalkanoic acid (PHA) containing large amounts of 3-hydroxy-cis-5-dodecenoate unit up to 35 mol% in the cell from unrelated substrates such as fructose, succinate, ... |
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Hyperpolarization of the cell membrane of mouse hepatocytes by fatty acid oxidation.
Physiol. Behav. 57(3) , 509-14, (1995) The effect of palmitate and metabolizable and nonmetabolizable monosacharides (D-glucose, D-fructose and 2-deoxy-D-glucose = 2-DG) on the membrane potential (Vm) of mouse hepatocytes was investigated employing a superfused mouse liver slice technique. Palmita... |
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Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture.
J. Biol. Chem. 267(21) , 14918-27, (1992) Hexanoate and octanoate inhibit the triiodothyronine (T3)-induced increases in the activities of malic enzyme and fatty acid synthase in chick embryo hepatocytes in culture. Butanoate was less effective as an inhibitor, and palmitate, stearate, and oleate had... |
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The involvement of carnitine intermediates in peroxisomal fatty acid oxidation: a study with 2-bromofatty acids.
Arch. Biochem. Biophys. 281(2) , 233-8, (1990) Metabolism-dependent inactivators of 3-ketothiolase I and carnitine acyltransferase I (CAT I) have been used to study the oxidation of fatty acids in intact hepatocytes. 2-Bromooctanoate inactivates mitochondrial and peroxisomal 3-ketothiolases I in a time-de... |
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Effects of inhibitors of diacylglycerol metabolism on protein kinase C-mediated responses in hepatocytes.
Biochim. Biophys. Acta 970(1) , 68-74, (1988) In hepatocytes pre-labelled with [3H]glycerol, compound R59022 (6-[2-(4-[(4-fluorophenyl)phenylmethylene]-1-piperidinyl)ethyl]-7- methyl-5H-thiazolo[3,2-alpha]pyrimidin-5-one) and 2-bromooctanoate each increased the amount of radioactivity in diacylglycerols.... |
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Quantitation of ketogenesis in periportal and pericentral regions of the liver lobule.
Arch. Biochem. Biophys. 253(1) , 26-37, (1987) A method has been devised to quantitate rates of ketogenesis (acetoacetate + beta-hydroxybutyrate production) in discrete regions of the liver lobule based on changes in NADH fluorescence. In perfused livers from fasted rats, ketogenesis was inhibited nearly ... |
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Increased diacylglycerol levels inhibit [20-3H]phorbol 12,13-dibutyrate binding and the glucocorticoid-mediated increase in glycerol phosphate phosphate dehydrogenase levels in C6 rat glioma cells.
J. Neurochem. 48(1) , 181-6, (1987) I examined whether the phorbol ester-mediated inhibition of glycerol 3-phosphate dehydrogenase (GPDH) induction could be mimicked by raising the cellular diacylglycerol levels. Phorbol ester tumor promoters and diacylglycerols activate protein kinase C. An in... |
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Inhibition of fatty acid oxidation by 2-bromooctanoate. Evidence for the enzymatic formation of 2-bromo-3-ketooctanoyl coenzyme A and the inhibition of 3-ketothiolase.
J. Biol. Chem. 254(14) , 6755-62, (1979) Incubation of rat liver mitochondria with 10 microM DL-2-bromooctanoate causes complete and irreversible inactivation of 3-ketothiolase I (acyl-CoA:acetyl-CoA C-acyltransferase). Evidence is presented that mitochondria convert bromooctanoate to 2-bromo-3-keto... |
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FadD from Pseudomonas putida CA-3 is a true long-chain fatty acyl coenzyme A synthetase that activates phenylalkanoic and alkanoic acids.
J. Bacteriol. 191(24) , 7554-65, (2009) A fatty acyl coenzyme A synthetase (FadD) from Pseudomonas putida CA-3 is capable of activating a wide range of phenylalkanoic and alkanoic acids. It exhibits the highest rates of reaction and catalytic efficiency with long-chain aromatic and aliphatic substr... |
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Metabolic induction of experimental ulcerative colitis by inhibition of fatty acid oxidation.
Br. J. Exp. Pathol. 67(6) , 773-82, (1986) There is some evidence that failure of fatty acid or beta-oxidation in the epithelium of the colonic mucosa is associated with the development of ulcerative colitis. We tested the hypothesis that inhibition of fatty acid oxidation in the colonic mucosa of the... |