2,4,6-trinitrobenzenesulfonic acid

2,4,6-trinitrobenzenesulfonic acid Structure
2,4,6-trinitrobenzenesulfonic acid structure
Common Name 2,4,6-trinitrobenzenesulfonic acid
CAS Number 2508-19-2 Molecular Weight 293.168
Density 2.0±0.1 g/cm3 Boiling Point N/A
Molecular Formula C6H3N3O9S Melting Point N/A
MSDS Chinese USA Flash Point 58 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

In vitro inhibition of lysine decarboxylase activity by organophosphate esters.

Biochem. Pharmacol. 92(3) , 506-16, (2014)

Organophosphate esters (OPEs), a major group of organophosphorus flame retardants, are regarded as emerging environmental contaminants of health concern. Amino acid decarboxylases catalyze the conversion of amino acids into polyamines that are essential for c...

Hirsutenone reduces deterioration of tight junction proteins through EGFR/Akt and ERK1/2 pathway both converging to HO-1 induction.

Biochem. Pharmacol. 90(2) , 115-25, (2014)

Oxidative stress-induced disruption of epithelial tight junctions (TJ) plays a critical role in the pathogenesis of intestinal disorders, including inflammatory bowel disease (IBD). The current study investigated the protective effect of hirsutenone against d...

Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis.

World J. Gastroenterol. 20(31) , 10876-85, (2014)

To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model.Rats were divided into seven groups. Four groups received oral butyrate, L-carnitine, Lactobacillus casei and the combination of t...

Quantification of Sorafenib in Human Serum by Competitive Enzyme-Linked Immunosorbent Assay.

Biol. Pharm. Bull. 38 , 1788-93, (2015)

The multikinase inhibitor sorafenib has been used in the treatment of hepatocellular carcinoma, renal cell carcinoma, and differentiated thyroid carcinoma. Here we have demonstrated the production of the first specific antibody against sorafenib. Anti-sorafen...

Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis.

Pharm. Biol. 53(3) , 429-36, (2015)

Tragopogon graminifolius DC. (Compositae) (TG) has been proposed as an efficacious remedy for gastrointestinal ulcers in Iranian traditional medicine.The present study evaluates the efficacy of TG on experimental colitis and the responsible mechanisms.After i...

Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.

J. Nutr. Biochem. 25(9) , 923-33, (2014)

Isorhamnetin is an O-methylated flavonol present in fruit and vegetables. We recently reported the identification of isorhamnetin as an activator of the human pregnane X receptor (PXR), a known target for abrogating inflammation in inflammatory bowel disease ...

Structure, size, and solubility of antigen arrays determines efficacy in experimental autoimmune encephalomyelitis.

AAPS J. 16(6) , 1185-93, (2014)

Presentation of antigen with immune stimulating "signal" has been a cornerstone of vaccine design for decades. Here, the antigen plus immune "signal" of vaccines is modified to produce antigen-specific immunotherapies (antigen-SITs) that can potentially repro...

Preparation and testing of a Haemophilus influenzae Type b/Hepatitis B surface antigen conjugate vaccine.

Vaccine 33(13) , 1614-9, (2015)

The majority of conjugate vaccines focus on inducing an antibody response to the polysaccharide antigen and the carrier protein is present primarily to induce a T-cell dependent response. In this study conjugates consisting of poly(ribosylribitolphosphate) (P...

Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function.

PLoS ONE 10 , e0128881, (2015)

Increased blood glucose concentrations promote reactions between glucose and proteins to form advanced glycation end-products (AGE). Circulating AGE in the blood plasma can activate the receptor for advanced end-products (RAGE), which is present on both endot...

Synthesis and Characterization of Hapten-Protein Conjugates for Antibody Production against Cyanogenic Glycosides.

J. Food Prot. 78 , 1408-13, (2015)

Consumption of cyanogenic plants can cause serious health problems for humans. The ability to detect and quantify cyanogenic glycosides, capable of generating cyanide, could contribute to prevention of cyanide poisoning from the consumption of improperly proc...