Bufuralol hydrochloride
Bufuralol hydrochloride structure
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Common Name | Bufuralol hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 60398-91-6 | Molecular Weight | 297.82000 | |
| Density | N/A | Boiling Point | 393.2ºC at 760 mmHg | |
| Molecular Formula | C16H24ClNO2 | Melting Point | 143-146ºC | |
| MSDS | Chinese USA | Flash Point | 191.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy.
Biochem. Biophys. Res. Commun. 343(3) , 772-9, (2006) Cytochrome P450 2D6 (CYP2D6) is one of the most important drug-metabolizing enzymes in humans. Resonance Raman data, reported for the first time for CYP2D6, show that the CYP2D6 heme is found to be in a six-coordinated low-spin state in the absence of substra... |
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The ability of cytochrome P450 2D isoforms to synthesize dopamine in the brain: An in vitro study.
Eur. J. Pharmacol. 626(2-3) , 171-8, (2010) The present study was aimed at determining which rat cytochrome P450 (CYP) isoforms are involved in the hydroxylation of tyramine to dopamine and at determining whether the reaction can take place in the brain. Moreover, we examined the relative distribution ... |
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Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.
Drug Metab. Dispos. 40(4) , 706-16, (2012) Cryopreserved human hepatocytes suspended in human plasma (HHSHP) have previously provided accurate CYP3A drug-drug interaction (DDI) predictions from a single IC(50) that captures both reversible and time-dependent inhibition. The goal of this study was to c... |
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Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells.
Stem Cells Transl. Med. 2(6) , 409-19, (2013) Human induced pluripotent stem cells (hiPSCs) hold great potential for use in regenerative medicine, novel drug development, and disease progression/developmental studies. Here, we report highly efficient differentiation of hiPSCs toward a relatively homogene... |
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Functional characterization of a first avian cytochrome P450 of the CYP2D subfamily (CYP2D49).
PLoS ONE 7(6) , e38395, (2012) The CYP2D family members are instrumental in the metabolism of 20-25% of commonly prescribed drugs. Although many CYP2D isoforms have been well characterized in other animal models, research concerning the chicken CYP2Ds is limited. In this study, a cDNA enco... |
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Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism.
FEBS J. 276(13) , 3440-53, (2009) Constitutively expressed human cytochrome P450 2D6 (CYP2D6; EC 1.14.14.1) is responsible for the metabolism of approximately 25% of drugs in common clinical use. It is widely accepted that CYP2D6 is localized in the endoplasmic reticulum of cells; however, we... |
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HPLC separation technique for analysis of bufuralol enantiomers in plasma and pharmaceutical formulations using a vancomycin chiral stationary phase and UV detection.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 856(1-2) , 328-36, (2007) A sensitive and selective high-performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of bufuralol enantiomers in plasma and pharmaceutical formulations. Enantiomeric resolution was achieved on a vancomycin macr... |
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New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes.
Drug Metab. Dispos. 34(8) , 1411-6, (2006) Genotype/phenotype analysis with human hepatocytes has identified a new inactive CYP2D6 allele, CYP2D6*56. Cryopreserved human hepatocytes from 51 livers were evaluated for CYP2D6 activity with dextromethorphan as the probe substrate. Hepatocyte lots that lac... |
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The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol.
Biochem. Pharmacol. 77(5) , 920-31, (2009) The capacity to oxidize bufuralol (BF) and dextromethorphan (DEX) was compared kinetically between human CYP2D6 and four rat CYP2D (CYP2D1, -2D2, -2D3 and -2D4) isoenzymes in a yeast cell expression system. In BF 1''-hydroxylation and DEX O-demethylation, onl... |
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Effect of oral administration of clinically relevant doses of dexamethasone on regulation of cytochrome P450 subfamilies in hepatic microsomes from dogs and rats.
Am. J. Vet. Res. 67(2) , 329-34, (2006) To evaluate the effect of oral administration of dexamethasone (DEX) at clinically relevant doses on metabolic activities of cytochrome P450 (CYP) isoenzymes in dogs and rats.15 healthy 1-year-old male Beagles and 20 healthy 10-week-old male Wistar rats.Hepat... |