(-)-MDO-NPA HCl
(-)-MDO-NPA HCl structure
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Common Name | (-)-MDO-NPA HCl | ||
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| CAS Number | 81264-57-5 | Molecular Weight | 307.38600 | |
| Density | 1.209g/cm3 | Boiling Point | 456ºC at 760 mmHg | |
| Molecular Formula | C20H21NO2 | Melting Point | 250-252ºC | |
| MSDS | USA | Flash Point | 165.2ºC | |
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Behavioral effects of (-)10,11-methylenedioxy-N-n-propylnoraporphine, an orally effective long-acting agent active at central dopamine receptors, and analogous aporphines.
Neuropharmacology 21(10) , 953-61, (1982) Substituted and unsubstituted 10,11-methylenedioxy derivatives of apomorphine (APO) or its N-propyl congener (NPA) were synthesized and evaluated for their ability to alter motor activity or to induce stereotyped behavior in the rat. Of these, (-)10,11-methyl... |
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Dopaminergic stimulation of oxytocin concentrations in the plasma of male and female monkeys by apomorphine and a D2 receptor agonist.
J. Clin. Endocrinol. Metab. 75(3) , 855-60, (1992) Administration of the dopamine receptor agonist apomorphine causes a dose-dependent increase in plasma oxytocin concentrations and dose-specific behavioral changes in rodents. To investigate whether dopamine receptor agonists will elicit similar neuroendocrin... |
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Tissue levels of N-n-propylnorapomorphine after treatment with (-)10,11-methylenedioxy-N-n-propylnoraporphine, an orally long-acting prodrug active at central dopamine receptors.
Neuropharmacology 21(12) , 1311-6, (1982) High performance liquid chromatography with electrochemical detection was used to assay N-n-propylnorapomorphine (NPA) and other aporphines. Pretreatment of rats with (-)10,11-methylenedioxy-N-n-propylnoraporphine (MDO-NPA) yielded dose-dependent increases in... |
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An orally effective, long-acting dopaminergic prodrug: (-)-10,11-methylenedioxy-N-propylnoraporphine.
Eur. J. Pharmacol. 77(1) , 87-8, (1982)
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(-)-10,11-Methylenedioxy-N-propylnoraporphine, an orally effective dopamine agonist and duodenal antiulcerogen in the rat.
Eur. J. Pharmacol. 88(2-3) , 273-4, (1983)
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High-performance liquid chromatographic separation and electrochemical or spectrophotometric determination of R(-)N-n-propylnorapomorphine and R(-)10,11-methylenedioxy-N-n-propylnoraporphine in primate plasma.
J. Chromatogr. A. 426(2) , 283-94, (1988) The dopamine receptor agonist R(-)N-n-propylnorapomorphine (NPA) and its proposed pro-drug R(-)10,11-methylenedioxy-N-n-propylnoraporphine (MDO-NPA) were isolated simultaneously from monkey plasma using a solid-phase extraction procedure. R(-)Apomorphine (APO... |
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Analysis of N-n-propylnorapomorphine in plasma and tissue by capillary gas chromatography--electron-capture detection.
J. Chromatogr. A. 274 , 149-59, (1983) Capillary gas chromatography combined with electron-capture detection (GC-ECD) was applied to the detection and quantitation of N-n-propylnorapomorphine (NPA) and related compounds in serum and tissue using trifluoroacetyl (TFA) derivatives. The detection lim... |
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S(+)methylenedioxy-N-n-propylnoraporphine: an orally active inhibitor of dopamine selective for rat limbic system.
Brain Res. 403(2) , 393-7, (1987) The 10-11-methylenedioxy (MDO) derivative of S(+)N-n-propylnorapomorphine (NPA) was prepared and tested as a possible active prodrug to S(+)NPA, which we have recently found to exert in vivo activity suggestive of selective antagonism of dopamine receptors in... |