DK-AH 269
DK-AH 269 structure
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Common Name | DK-AH 269 | ||
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| CAS Number | 186097-54-1 | Molecular Weight | 519.07300 | |
| Density | N/A | Boiling Point | 655.7ºC at 760 mmHg | |
| Molecular Formula | C28H39ClN2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 350.4ºC | |
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Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine.
Eur. J. Pharmacol. 478 , 161-171, (2003) The action of the bradycardiac agents, cilobradine (DK-AH269) and zatebradine (UL-FS49), on the cardiac pacemaker current (If) was investigated on short Purkinje fibres from sheep hearts, using the two-microelectrode voltage-clamp technique, and on isolated r... |
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Bradycardic and proarrhythmic properties of sinus node inhibitors.
Mol. Pharmacol. 69 , 1328-1337, (2006) Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system. This pacemaker current is carried by four hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels. We tested the p... |
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Use-dependent block of Ih in mouse dorsal root ganglion neurons by sinus node inhibitors.
Br. J. Pharmacol. 125 , 741-750, (1998) 1. The sinus node inhibitors UL FS 49 and DK-AH 269 reduce heart rate by slowing diastolic depolarization rate in the sino-atrial (SA) node, which might originate from the use-dependent blockade of a hyperpolarization-activated current If. A hyperpolarization... |
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Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP.
Proc. Natl. Acad. Sci. U. S. A. 99 , 9538-9543, (2002) Hyperpolarization-activated nonselective cation channels (Ih channels) play an important role in the control of membrane excitability and rhythmic neuronal activity. The functional relevance of presynaptic Ih channels in regulating synaptic function, however,... |
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Specific bradycardic agents block the hyperpolarization-activated cation current in central neurons.
Neuroscience 59 , 363-373, (1994) A class of pharmacologically active substances, known as "specific bradycardic agents", exerts a negative chronotropic influence on cardiac activity, which heavily relies upon a potent blockade of the hyperpolarization-activated cation current in Purkinje fib... |